Altered gut microbiome composition by appendectomy contributes to colorectal cancer.
Altered gut microbiome composition by appendectomy contributes to colorectal cancer.
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阑尾切除术改变肠道微生物组成导致结直肠癌
DOI：
10.1038/s41388-022-02569-3
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发表时间：
2023-03
期刊：
影响因子：
8
通讯作者：
She, Junjun
中科院分区：
文献类型：
--
作者：
Shi, Feiyu;Liu, Gaixia;Lin, Yufeng;Guo, Cosmos Liutao;Han, Jing;Chu, Eagle S. H.;Shi, Chengxin;Li, Yaguang;Zhang, Haowei;Hu, Chenhao;Liu, Ruihan;He, Shuixiang;Guo, Gang;Chen, Yinnan;Zhang, Xiang;Coker, Olabisi Oluwabukola;Wong, Sunny Hei;Yu, Jun;She, Junjun
Appendectomy impacts the homeostasis of gut microbiome in patients. We aimed to study the role of appendectomy in colorectal cancer (CRC) risk through causing gut microbial dysbiosis. Population-based longitudinal study (cohort 1, n = 129,155) showed a 73.0% increase in CRC risk among appendectomy cases throughout 20 years follow-up (Adjusted sub-distribution hazard ratio (SHR) 1.73, 95% CI 1.49–2.01, P < 0.001). Shotgun metagenomic sequencing was performed on fecal samples from cohort 2 (n = 314). Gut microbial dysbiosis in appendectomy subjects was observed with significant enrichment of 7 CRC-promoting bacteria (Bacteroides vulgatus, Bacteroides fragilis, Veillonella dispar, Prevotella ruminicola, Prevotella fucsa, Prevotella dentalis, Prevotella denticola) and depletion of 5 beneficial commensals (Blautia sp YL58, Enterococcus hirae, Lachnospiraceae bacterium Choco86, Collinsella aerofaciens, Blautia sp SC05B48). Microbial network analysis showed increased correlation strengths among enriched bacteria and their enriched oncogenic pathways in appendectomy subjects compared to controls. Of which, B. fragilis was the centrality in the network of the enriched bacteria. We further confirmed that appendectomy promoted colorectal tumorigenesis in mice by causing gut microbial dysbiosis and impaired intestinal barrier function. Collectively, this study revealed appendectomy-induced microbial dysbiosis characterized by enriched CRC-promoting bacteria and depleted beneficial commensals, signifying that the gut microbiome may play a crucial role in CRC development induced by appendectomy.
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影响因子：
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作者：
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影响因子：
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作者：
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DOI：
10.1073/pnas.1010203108
发表时间：
2011-09-13
影响因子：
11.1
作者：
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