Association between perinatal mortality and morbidity and customised and non-customised birthweight centiles in Denmark, Finland, Norway, Wales, and England: comparative, population based, record linkage study.
Association between perinatal mortality and morbidity and customised and non-customised birthweight centiles in Denmark, Finland, Norway, Wales, and England: comparative, population based, record linkage study.
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DOI：
10.1136/bmjmed-2023-000521
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Lawlor, Deborah A.
中科院分区：
文献类型：
--
作者：
Kilpi, Fanny;Jones, Hayley E.;Magnus, Maria Christine;Santorelli, Gillian;Hojsgaard Schmidt, Lise Kristine;Urhoj, Stine Kjaer;Nelson, Scott M.;Tuffnell, Derek;French, Robert;Magnus, Per Minor;Nybo Andersen, Anne-Marie;Martikainen, Pekka;Tilling, Kate;Lawlor, Deborah A.
根据出生时小于胎龄（SGA; <第10百分位数）或大于胎龄（LGA; >第90百分位数）的婴儿，比较不良围产期结局的风险，定义为非定制的出生体重百分位数（即仅按性别和胎龄标准化）和定制的出生体重百分位数（按性别、胎龄、母体体重、身高、产次和种族）。比较性、基于人群的记录关联研究，并对结果进行荟萃分析。丹麦、芬兰、挪威、威尔士和英格兰（布拉德福德市），1986-2019年。2 129 782名在出生登记处出生的足月婴儿。死胎、新生儿死亡、婴儿死亡、进入新生儿重症监护室和5分钟时的低Apgar评分（<7）。相对于平均胎龄（阿加）出生的婴儿，SGA和LGA出生的所有五种结局的风险均增加，但观察到的相对风险相似，无论是否使用非定制或定制图表。例如，对于SGA与阿加出生，当使用非定制和定制图表时，各国合并的相对风险为3.60（95%置信区间3.29至3.93）与3.58（3.02至4.24）死产，2.83（2.18至3.67）对比3.32（2.05至5.36）新生儿死亡，2.82（2.07至3.83）对比3.17（2.20至4.56）婴儿死亡，1.66（1.49至1.86）对1.54（1.30 - 1.81），（仅基于Bradford数据）1.97（1.74 - 2.22）与1.94（1.70 - 2.21），入院新生儿重症监护室。对于非定制图表，合并SGA或LGA出生识别三种死亡率结局的估计灵敏度范围为31%至34%，对于定制图表为34%至38%，对于非定制图表和定制图表的特异性分别为82%和80%。这些结果表明，当使用定制和非定制百分位数时，SGA或LGA足月儿中不良围产期结局的风险增加幅度相似。在SGA/LGA出生时使用定制图表-超过SGA/LGA出生时使用非定制图表-不太可能在识别有这些结局风险的足月分娩方面提供益处。
To compare the risk of adverse perinatal outcomes according to infants who are born small for gestational age (SGA; <10th centile) or large for gestational age (LGA; >90th centile), as defined by birthweight centiles that are non-customised (ie, standardised by sex and gestational age only) and customised (by sex, gestational age, maternal weight, height, parity, and ethnic group). Comparative, population based, record linkage study with meta-analysis of results. Denmark, Finland, Norway, Wales, and England (city of Bradford), 1986-2019. 2 129 782 infants born at term in birth registries. Stillbirth, neonatal death, infant death, admission to neonatal intensive care unit, and low Apgar score (<7) at 5 minutes. Relative to those infants born average for gestational age (AGA), both SGA and LGA births were at increased risk of all five outcomes, but observed relative risks were similar irrespective of whether non-customised or customised charts were used. For example, for SGA versus AGA births, when non-customised and customised charts were used, relative risks pooled over countries were 3.60 (95% confidence interval 3.29 to 3.93) versus 3.58 (3.02 to 4.24) for stillbirth, 2.83 (2.18 to 3.67) versus 3.32 (2.05 to 5.36) for neonatal death, 2.82 (2.07 to 3.83) versus 3.17 (2.20 to 4.56) for infant death, 1.66 (1.49 to 1.86) versus 1.54 (1.30 to 1.81) for low Apgar score at 5 minutes, and (based on Bradford data only) 1.97 (1.74 to 2.22) versus 1.94 (1.70 to 2.21) for admission to the neonatal intensive care unit. The estimated sensitivity of combined SGA or LGA births to identify the three mortality outcomes ranged from 31% to 34% for non-customised charts and from 34% to 38% for customised charts, with a specificity of 82% and 80% with non-customised and customised charts, respectively. These results suggest an increased risk of adverse perinatal outcomes of a similar magnitude among SGA or LGA term infants when customised and non-customised centiles are used. Use of customised charts for SGA/LGA births—over and above use of non-customised charts for SGA/LGA births—is unlikely to provide benefits in terms of identifying term births at risk of these outcomes.
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影响因子：
7.7
作者：
Wilcox, AJ
通讯作者：
Wilcox, AJ
影响因子：
3.1
作者：
Kamphof, Hester D.;Gordijn, Sanne J.;Ganzevoort, Wessel;Verfaille, Viki;Offerhaus, Pien M.;Franx, Arie;Pajkrt, Eva;de Jonge, Ank;Henrichs, Jens
通讯作者：
Henrichs, Jens
影响因子：
2.5
作者：
Relph S;Elstad M;Coker B;Vieira MC;Moitt N;Gutierrez WM;Khalil A;Sandall J;Copas A;Lawlor DA;Pasupathy D;DESIGN Trial team
通讯作者：
DESIGN Trial team
影响因子：
168.9
作者：
GARDOSI, J;CHANG, A;SYMONDS, EM
通讯作者：
SYMONDS, EM
影响因子：
3.8
作者：
Hua, Xiaolin;Shen, Minxue;Zhang, Jun
通讯作者：
Zhang, Jun