Hepcidin regulation of iron transport.
Hepcidin regulation of iron transport.
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DOI:
10.3945/jn.108.096347
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发表时间:
2008-11
期刊:
影响因子:
--
通讯作者:
Knutson MD
中科院分区:
文献类型:
--
作者:
Collins JF;Wessling-Resnick M;Knutson MD
The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.
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