Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the 'Women First' maternal preconception nutrition randomised controlled trial.
Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the 'Women First' maternal preconception nutrition randomised controlled trial.
复制标题
DOI：
10.1136/archdischild-2023-325352
复制
发表时间：
2023-08
影响因子：
5.2
通讯作者：
Hambidge, K. Michael
中科院分区：
文献类型：
--
作者：
Fernandes, Michelle;Krebs, Nancy F.;Westcott, Jamie;Tshefu, Antoinette;Lokangaka, Adrien;Bauserman, Melissa;Garces, Ana L.;Figueroa, Lester;Saleem, Sarah;Aziz, Sumera A.;Goldenberg, Robert L.;Goudar, Shivaprasad S.;Dhaded, Sangappa M.;Derman, Richard J.;Kemp, Jennifer F.;Koso-Thomas, Marion;Sridhar, Amaanti;McClure, Elizabeth;Hambidge, K. Michael
孕前和妊娠早期的母体营养影响胎儿生长。在低收入和中等收入国家，产前产妇营养对儿童早期发育(ECD)影响的证据有限。研究孕前或孕期开始的母体营养补充对ECD的影响，并研究出生后发育与ECD领域的潜在关联。关于多国母体个体随机试验参与者子女的二次分析。刚果民主共和国、危地马拉、印度和巴基斯坦的农村。667名女性首次试验参与者的后代，年龄24个月。孕妇在怀孕前(第1组，n=217)、妊娠12周(第2组，n=230)或未怀孕(第3组，n=220)开始补充脂类营养；干预在分娩时停止。共生-21世纪神经发育评估(Inter-NDA)：认知、语言、粗大运动、精细运动、积极和消极行为评分；视力和对比敏感度评分；听觉诱发反应电位(ERP)评分。人体测量Z分数、家庭护理指标(FCI)和社会人口学变量被作为协变量检验。在不同领域的NDA间评分、视力评分或事件相关电位方面，干预组之间均未发现显著差异。在调整协变量后，24个月的年龄长度z得分(LAZ24)、社会经济状况、母亲教育程度和FCI显著预测视力和NDA得分(R2=0.11-0.38，p<；0.01)。产前补充母体营养与2岁时的任何神经发育结果无关。母亲文化程度、家庭环境和LAZ24可预测ECD。针对养育模式的多个组成部分的干预措施可能会对儿童的发展潜力产生最大的影响。NCT01883193。
Maternal nutrition in preconception and early pregnancy influences fetal growth. Evidence for effects of prenatal maternal nutrition on early child development (ECD) in low-income and middle-income countries is limited. To examine impact of maternal nutrition supplementation initiated prior to or during pregnancy on ECD, and to examine potential association of postnatal growth with ECD domains. Secondary analysis regarding the offspring of participants of a maternal multicountry, individually randomised trial. Rural Democratic Republic of the Congo, Guatemala, India and Pakistan. 667 offspring of Women First trial participants, aged 24 months. Maternal lipid-based nutrient supplement initiated preconceptionally (arm 1, n=217), 12 weeks gestation (arm 2, n=230) or not (arm 3, n=220); intervention stopped at delivery. The INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) cognitive, language, gross motor, fine motor, positive and negative behaviour scores; visual acuity and contrast sensitivity scores and auditory evoked response potentials (ERP). Anthropometric z-scores, family care indicators (FCI) and sociodemographic variables were examined as covariates. No significant differences were detected among the intervention arms for any INTER-NDA scores across domains, vision scores or ERP potentials. After adjusting for covariates, length-for-age z-score at 24 months (LAZ24), socio-economic status, maternal education and FCI significantly predicted vision and INTER-NDA scores (R2=0.11–0.38, p<0.01). Prenatal maternal nutrition supplementation was not associated with any neurodevelopmental outcomes at age 2 years. Maternal education, family environment and LAZ24 predicted ECD. Interventions addressing multiple components of the nurturing care model may offer greatest impact on children’s developmental potential. NCT01883193.
登录
查看更多内容
DOI：
10.1016/j.clinph.2009.11.086
发表时间：
2010-04
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Kihara M;Hogan AM;Newton CR;Garrashi HH;Neville BR;de Haan M
通讯作者：
de Haan M
DOI：
10.1016/s0140-6736(16)31389-7
发表时间：
2017-01-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Black MM;Walker SP;Fernald LCH;Andersen CT;DiGirolamo AM;Lu C;McCoy DC;Fink G;Shawar YR;Shiffman J;Devercelli AE;Wodon QT;Vargas-Barón E;Grantham-McGregor S;Lancet Early Childhood Development Series Steering Committee
通讯作者：
Lancet Early Childhood Development Series Steering Committee
在“妇女首先”孕妇营养试验中，母亲的婴儿从出生到六个月的生长。
DOI：
10.1016/j.jpeds.2020.09.032
发表时间：
2021-03
期刊：
The Journal of pediatrics
影响因子：
--
作者：
Krebs NF;Hambidge KM;Westcott JL;Garcés AL;Figueroa L;Tsefu AK;Lokangaka AL;Goudar SS;Dhaded SM;Saleem S;Ali SA;Bose CL;Derman RJ;Goldenberg RL;Thorsten VR;Sridhar A;Chowdhury D;Das A;Women First Preconception Maternal Nutrition Study Group
通讯作者：
Women First Preconception Maternal Nutrition Study Group
影响因子：
3.1
作者：
Hambidge KM;Krebs NF;Westcott JE;Garces A;Goudar SS;Kodkany BS;Pasha O;Tshefu A;Bose CL;Figueroa L;Goldenberg RL;Derman RJ;Friedman JE;Frank DN;McClure EM;Stolka K;Das A;Koso-Thomas M;Sundberg S;Preconception Trial Group
通讯作者：
Preconception Trial Group
DOI：
10.1093/ajcn/nqaa423
发表时间：
2021-05-08
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Nguyen PH;Young MF;Tran LM;Khuong LQ;Duong TH;Nguyen HC;Truong TV;DiGirolamo AM;Martorell R;Ramakrishnan U
通讯作者：
Ramakrishnan U