Acceleration of small bowel motility after oral administration of dai-kenchu-to (TJ-100) assessed by cine magnetic resonance imaging.
Acceleration of small bowel motility after oral administration of dai-kenchu-to (TJ-100) assessed by cine magnetic resonance imaging.
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DOI：
10.1371/journal.pone.0191044
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Murata K
中科院分区：
文献类型：
--
作者：
Inoue A;Furukawa A;Yamamoto H;Ohta S;Linh NDH;Syerikjan T;Kaida S;Yamaguchi T;Murata S;Obata T;Tani M;Murata K
Dai-kenchu-to（TJ-100）是一种草药，用于通过加速肠道运动来缩短肠道传输的持续时间。然而，由于暴露于电离辐射，健康志愿者的肠道运动本身还没有使用X线摄影，荧光透视和放射性同位素进行评估。本研究的目的是使用具有稳态自由进动序列的电影磁共振成像（电影MRI）评价TJ-100对肠运动的影响。10名健康男性志愿者接受了5g TJ-100或乳糖，但未披露物质的身份。每名志愿者在不同的日子服用物质（TJ-100和乳糖）后接受两次MRI检查。他们喝了1200毫升自来水，并在10分钟后进行电影MRI。稳态自由进动序列用于成像，在0，10，20，30，40和50分钟进行三次。评估肠道收缩频率和扩张评分。使用Wilcoxon符号秩检验，并且在P值<0.05时认为差异是显著的。TJ-100组中的肠收缩频率倾向于更大，并且在20分钟（TJ-100，8.95 ± 2.88;乳糖，4.80 ± 2.92; P < 0.05）和50分钟（TJ-100，9.45 ± 4.49;乳糖，4.45 ± 2.65; P < 0.05）时，组间回肠中的收缩频率存在显著差异。肠扩张评分无显著差异。电影MRI显示TJ-100激活肠运动而不依赖于回肠扩张。
Dai-kenchu-to (TJ-100) is an herbal medicine used to shorten the duration of intestinal transit by accelerating intestinal movement. However, intestinal movement in itself has not been evaluated in healthy volunteers using radiography, fluoroscopy, and radioisotopes because of exposure to ionizing radiation. The purpose of this study was to evaluate the effect of TJ-100 on intestinal motility using cinematic magnetic resonance imaging (cine MRI) with a steady-state free precession sequence. Ten healthy male volunteers received 5 g of either TJ-100 or lactose without disclosure of the identity of the substance. Each volunteer underwent two MRI examinations after taking the substances (TJ-100 and lactose) on separate days. They drank 1200 mL of tap water and underwent cine MRI after 10 min. A steady-state free precession sequence was used for imaging, which was performed thrice at 0, 10, 20, 30, 40, and 50 min. The bowel contraction frequency and distention score were assessed. Wilcoxon signed-rank test was used, and differences were considered significant at a P-value <0.05. The bowel contraction frequency tended to be greater in the TJ-100 group and was significantly different in the ileum at 20 (TJ-100, 8.95 ± 2.88; lactose, 4.80 ± 2.92; P < 0.05) and 50 min (TJ-100, 9.45 ± 4.49; lactose, 4.45 ± 2.65; P < 0.05) between the groups. No significant differences were observed in the bowel distention scores. Cine MRI demonstrated that TJ-100 activated intestinal motility without dependence on ileum distention.
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影响因子：
19.7
作者：
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通讯作者：
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