Association between physical activity status and severity of COVID-19 in older adults
Association between physical activity status and severity of COVID-19 in older adults
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老年人体力活动状况与 COVID-19 严重程度之间的关联
DOI：
10.1017/s0950268822001686
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发表时间：
2022
影响因子：
4.2
通讯作者：
Ohmagari Norio
中科院分区：
文献类型：
--
作者：
Tsuzuki Shinya;Akiyama Takayuki;Matsunaga Nobuaki;Ohmagari Norio
由Omicron Variant Of Concern(VOC)引起的2019年严重冠状病毒病(新冠肺炎)的老年人群特有的风险因素尚不清楚。我们对2022年1月1日至2022年5月16日期间入住医疗机构的4,868名严重急性呼吸道冠状病毒2型(SARS-CoV-2)检测阳性的老年人进行了Logistic回归分析，以确定严重新冠肺炎疾病的危险因素。然后，我们对三个因素--痴呆症、长期护理机构入院和体力活动状况不佳--进行了一对一的倾向评分(PS)匹配，并使用费舍尔精确检验来比较匹配数据中严重新冠肺炎病例的比例。我们还在每个PS匹配分析中估计了治疗(ATT)的平均治疗效果。在分析的4868例病例中，1380例病情严重。Logistic回归分析显示，年龄、男性、心血管疾病、脑血管疾病、慢性肺部疾病、肾功能衰竭和/或透析、医生诊断的肥胖、长期护理机构入院和体力活动状况差是重症疾病的危险因素。接种疫苗和痴呆症被确定为与非严重疾病相关的因素。痴呆症、长期护理机构入院和体力活动状态的ATT值分别为−0.04(95%可信区间−0.07至−0.01)、0.09(0.06至0.12)和0.17(0.14至0.19)。我们的结果表明，较差的体力活动状况和生活在长期护理机构与由奥米克龙挥发性有机化合物引起的严重新冠肺炎的风险有很大关联，而痴呆症可能与非严重疾病有关。
The risk factors specific to the elderly population for severe coronavirus disease 2019 (COVID-19) caused by the Omicron variant of concern (VOC) are not yet clear. We performed an exploratory analysis using logistic regression to identify risk factors for severe COVID-19 illness among 4,868 older adults with a positive severe acute respiratory coronavirus 2 (SARS-CoV-2) test result who were admitted to a healthcare facility between 1 January 2022 and 16 May 2022. We then conducted one-to-one propensity score (PS) matching for three factors – dementia, admission from a long-term care facility and poor physical activity status – and used Fisher's exact test to compare the proportion of severe COVID-19 cases in the matched data. We also estimated the average treatment effect on treated (ATT) in each PS matching analysis. Of the 4,868 cases analysed, 1,380 were severe. Logistic regression analysis showed that age, male sex, cardiovascular disease, cerebrovascular disease, chronic lung disease, renal failure and/or dialysis, physician-diagnosed obesity, admission from a long-term care facility and poor physical activity status were risk factors for severe disease. Vaccination and dementia were identified as factors associated with non-severe illness. The ATT for dementia, admission from a long-term care facility and poor physical activity status was −0.04 (95% confidence interval −0.07 to −0.01), 0.09 (0.06 to 0.12) and 0.17 (0.14 to 0.19), respectively. Our results suggest that poor physical activity status and living in a long-term care facility have a substantial association with the risk of severe COVID-19 caused by the Omicron VOC, while dementia may be associated with non-severe illness.
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DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
影响因子：
2.2
作者：
Shoji, Kensuke;Tsuzuki, Shinya;Akiyama, Takayuki;Matsunaga, Nobuaki;Asai, Yusuke;Suzuki, Setsuko;Iwamoto, Noriko;Funaki, Takanori;Yamada, Masaki;Ozawa, Nobuaki;Yamaguchi, Koushi;Miyairi, Isao;Ohmagari, Norio
通讯作者：
Ohmagari, Norio
影响因子：
1.6
作者：
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通讯作者：
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DOI：
10.1002/jcsm.12966
发表时间：
2022-06
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
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作者：
通讯作者：
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影响因子：
18.4
作者：
Steenkamp L;Saggers RT;Bandini R;Stranges S;Choi YH;Thornton JS;Hendrie S;Patel D;Rabinowitz S;Patricios J
通讯作者：
Patricios J