Full thickness macular hole case after intravitreal aflibercept treatment.
Full thickness macular hole case after intravitreal aflibercept treatment.
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DOI：
10.1186/s12886-015-0021-3
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发表时间：
2015-03-29
影响因子：
2
通讯作者：
Ishibashi T
中科院分区：
文献类型：
--
作者：
Oshima Y;Apte RS;Nakao S;Yoshida S;Ishibashi T
黄斑裂孔形成的机制被广泛认为是在中央凹的玻璃体-视网膜界面处的牵引力。我们报告了一例玻璃体内注射阿柏西普治疗年龄相关性黄斑变性（AMD）后黄斑裂孔的病例，该病例与纤维血管性色素上皮脱离（PED）边缘的视网膜色素上皮（RPE）收缩相关。一名94岁男性，患有累及左眼的新生血管性AMD，伴有纤维血管性PED，检查其严重视力丧失。虽然在进行第一次阿柏西普玻璃体内注射以治疗新生血管性AMD之前确定了他左眼的RPE撕裂，但他接受了三次阿柏西普注射作为诱导治疗。诱导治疗后，全层黄斑裂孔被确定与视网膜下的收缩卷起的RPE边缘相关。黄斑裂孔的形成通常与切向玻璃体牵引有关。目前的报道表明，视网膜下RPE的快速收缩可能是黄斑裂孔的原因之一，也是新生血管性AMD抗VEGF治疗的副作用之一。
The pathogenesis of macular hole formation is widely accepted as a tractional force at the vitreo-retinal interface in fovea. We report a case of macular hole after intravitreous aflibercept injection for age-related macular degeneration (AMD) associated with contraction of the retinal pigment epithelium (RPE) at the edge of a fibrovascular pigment epithelial detachment (PED). A 94-year old man with neovascular AMD affecting his left eye accompanied by a fibrovascular PED was examined for severe vision loss. Although RPE tear in his left eye was identified before the first aflibercept intravitreous injection performed in order to treat neovascular AMD, he received three aflibercept injections as induction treatment. After induction treatment, a full thickness macular hole was identified associated with the contracted rolled RPE edge beneath the retina. Macular hole is commonly formed associated with tangential vitreous traction. Current report suggests that rapid contraction of the RPE underneath the retina can be one of the causes of a macular hole, and one of the side effects of anti-VEGF therapy for neovascular AMD.
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影响因子：
2
作者：
Okamoto T;Shinoda H;Kurihara T;Nagai N;Tsubota K;Ozawa Y
通讯作者：
Ozawa Y
特发性玻璃体术和黄斑孔：对病理生理，诊断和治疗的全面综述。
DOI：
10.1038/eye.2013.212
发表时间：
2013-10
期刊：
Eye (London, England)
影响因子：
--
作者：
Steel DH;Lotery AJ
通讯作者：
Lotery AJ
影响因子：
4.2
作者：
Nagiel, Aaron;Freund, K. Bailey;Sarraf, David
通讯作者：
Sarraf, David
影响因子：
0.4
作者：
Moisseiev, Elad;Goldstein, Michaela;Moisseiev, Joseph
通讯作者：
Moisseiev, Joseph
影响因子：
1.7
作者：
Grigoropoulos, Vlassis;Emfietzoglou, John;Theodossiadis, Panagiotis
通讯作者：
Theodossiadis, Panagiotis