Tissue specific expression of angiotensin converting enzyme: a new way to study an old friend.
Tissue specific expression of angiotensin converting enzyme: a new way to study an old friend.
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血管紧张素转换酶的组织特异性表达：研究老朋友的新方法。
DOI：
10.1016/j.intimp.2007.08.010
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发表时间：
2008
影响因子：
5.6
通讯作者：
Bernstein,KennethE
中科院分区：
文献类型：
--
作者：
Shen,XiaoZ;Xiao,HongD;Li,Ping;Billet,Sandrine;Lin,ChentaoX;Fuchs,Sebastien;Bernstein,KennethE
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Angiotensin-converting enzyme (ACE) plays a central role in blood pressure regulation by producing the vasoconstrictor angiotensin II. When ACE knockout mice were studied, they presented with a complicated phenotype, including cardiovascular, reproductive, hematologic and developmental defects. The complexity of an ACE knockout mouse emphasizes the advantages and disadvantages of the classic knockout strategy. An animal lacking all ACE is very different from a wild type animal, and can be modeled as representing an extreme phenotype. To understand the role of ACE in a tissue and organ specific fashion, our group used targeted homologous recombination to create mouse models in which a promoter swapping strategy results in very restricted tissue patterns of ACE expression. Mice with ACE expression only in the heart, termed ACE 8/8 mice, present with atria enlargement and electrical conduction defects, but normal ventricular function. Mice with ACE expression only in monocytes and macrophages, termed ACE 10/10 mice, have a marked resistance to the growth of melanoma due to an enhanced immune response characterized by increased tumor specific CD8+T cells and increased proinflammatory cytokines. These mice may define a new means of augmenting the immune response, potentially useful in human clinical situations. The promoter swapping strategy permits scientific investigation of questions unapproachable by other experimental approaches.
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影响因子：
7.8
作者：
Huang, S;Deerinck, TJ;Ellisman, MH;Spector, DL
通讯作者：
Spector, DL
DOI：
10.1083/jcb.111.6.2427
发表时间：
1990-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lyons GE;Schiaffino S;Sassoon D;Barton P;Buckingham M
通讯作者：
Buckingham M
喹那普利的抗炎作用
影响因子：
3.4
作者：
J. Egido;M. Ruíz
通讯作者：
M. Ruíz
B16 小鼠黑色素瘤的核型分析并重新评估正常小鼠的表型。
DOI：
10.1093/jnci/45.4.789
发表时间：
1970
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
E. M. Stephenson;N. Stephenson
通讯作者：
N. Stephenson