Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project.
Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project.
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DOI：
10.1093/ije/dyx031
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发表时间：
2017-10-01
影响因子：
7.7
通讯作者：
Silventoinen K
中科院分区：
文献类型：
--
作者：
Jelenkovic A;Yokoyama Y;Sund R;Pietiläinen KH;Hur YM;Willemsen G;Bartels M;van Beijsterveldt TCEM;Ooki S;Saudino KJ;Stazi MA;Fagnani C;D'Ippolito C;Nelson TL;Whitfield KE;Knafo-Noam A;Mankuta D;Abramson L;Heikkilä K;Cutler TL;Hopper JL;Wardle J;Llewellyn CH;Fisher A;Corley RP;Huibregtse BM;Derom CA;Vlietinck RF;Loos RJF;Bjerregaard-Andersen M;Beck-Nielsen H;Sodemann M;Tarnoki AD;Tarnoki DL;Burt SA;Klump KL;Ordoñana JR;Sánchez-Romera JF;Colodro-Conde L;Dubois L;Boivin M;Brendgen M;Dionne G;Vitaro F;Harris JR;Brandt I;Nilsen TS;Craig JM;Saffery R;Rasmussen F;Tynelius P;Bayasgalan G;Narandalai D;Haworth CMA;Plomin R;Ji F;Ning F;Pang Z;Rebato E;Krueger RF;McGue M;Pahlen S;Boomsma DI;Sørensen TIA;Kaprio J;Silventoinen K
有证据表明，出生体重与以后的身体质量指数（BMI）呈正相关，但尚不清楚这是由遗传因素还是宫内环境来解释的。我们分析了双胞胎从婴儿期到成年期出生体重和体重指数之间的关系，这为遗传和环境个体特定因素的作用提供了见解。这项研究基于来自17个国家的27个双胞胎队列的数据。汇总的数据包括78 642对双胞胎（20 635对同卵双胞胎和18 686对同性异卵双胞胎）的出生体重信息和214 930个年龄在1至49岁之间的BMI测量值。使用线性回归分析在个体和对内水平上分析出生体重和BMI之间的关系。在个体水平上，出生体重每增加1 kg与BMI升高0.9 kg/m2呈线性相关（P < 0.001）。在双胞胎中，回归系数通常大于个体水平分析的回归系数（高达1.2 kg/m2 / kg出生体重，P < 0.001）。在合子组和性别中，出生体重和后来的BMI之间的配对内关联相似，在成年期则较低。这些发现表明，环境因素对每个人来说都是独一无二的，在出生体重和后来的身体质量指数之间的正相关关系中起着重要作用，至少在成年早期是如此。
There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.
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影响因子：
64.8
作者：
Horikoshi, Momoko;Beaumont, Robin N.;Day, Felix R.;Warrington, Nicole M.;Kooijman, Marjolein N.;Fernandez-Tajes, Juan;Feenstra, Bjarke;van Zuydam, Natalie R.;Gaulton, Kyle J.;Grarup, Niels;Bradfield, Jonathan P.;Strachan, David P.;Li-Gao, Ruifang;Ahluwalia, Tarunveer S.;Kreiner, Eskil;Rueedi, Rico;Lyytikainen, Leo-Pekka;Cousminer, Diana L.;Wu, Ying;Thiering, Elisabeth;Wang, Carol A.;Have, Christian T.;Hottenga, Jouke-Jan;Vilor-Tejedor, Natalia;Joshi, Peter K.;Boh, Eileen Tai Hui;Ntalla, Ioanna;Pitkanen, Niina;Mahajan, Anubha;van Leeuwen, Elisabeth M.;Joro, Raimo;Lagou, Vasiliki;Nodzenski, Michael;Diver, Louise A.;Zondervan, Krina T.;Bustamante, Mariona;Marques-Vidal, Pedro;Mercader, Josep M.;Bennett, Amanda J.;Rahmioglu, Nilufer;Nyholt, Dale R.;Ma, Ronald C. W.;Tam, Claudia H. T.;Tam, Wing Hung;Ganesh, Santhi K.;van Rooij, Frank J. A.;Jones, Samuel E.;Loh, Po-Ru;Ruth, Katherine S.;Tuke, Marcus A.;Tyrrell, Jessica;Wood, Andrew R.;Yaghootkar, Hanieh;Scholtens, Denise M.;Paternoster, Lavinia;Prokopenko, Inga;Kovacs, Peter;Atalay, Mustafa;Willems, Sara M.;Panoutsopoulou, Kalliope;Wang, Xu;Carstensen, Lisbeth;Geller, Frank;Schraut, Katharina E.;Murcia, Mario;van Beijsterveldt, Catharina E. M.;Willemsen, Gonneke;Appel, Emil V. R.;Fonvig, Cilius E.;Trier, Caecilie;Tiesler, Carla M. T.;Standl, Marie;Kutalik, Zoltan;Bonas-Guarch, Silvia;Hougaard, David M.;Sanchez, Friman;Torrents, David;Waage, Johannes;Hollegaard, Mads V.;de Haan, Hugoline G.;Rosendaal, Frits R.;Medina-Gomez, Carolina;Ring, Susan M.;Hemani, Gibran;McMahon, George;Robertson, Neil R.;Groves, Christopher J.;Langenberg, Claudia;Luan, Jian'an;Scott, Robert A.;Zhao, Jing Hua;Mentch, Frank D.;MacKenzie, Scott M.;Reynolds, Rebecca M.;Lowe, William L.;Toenjes, Anke;Stumvoll, Michael;Lindi, Virpi;Lakka, Timo A.;van Duijn, Cornelia M.;Kiess, Wieland;Koerner, Antje;Sorensen, Thorkild I. A.;Niinikoski, Harri;Pahkala, Katja;Raitakari, Olli T.;Zeggini, Eleftheria;Dedoussis, George V.;Teo, Yik-Ying;Saw, Seang-Mei;Melbye, Mads;Campbell, Harry;Wilson, James F.;Vrijheid, Martine;de Geus, Eco J. C. N.;Boomsma, Dorret I.;Kadarmideen, Haja N.;Holm, Jens-Christian;Hansen, Torben;Sebert, Sylvain;Hattersley, Andrew T.;Beilin, Lawrence J.;Newnham, John P.;Pennell, Craig E.;Heinrich, Joachim;Adair, Linda S.;Borja, Judith B.;Mohlke, Karen L.;Eriksson, Johan G.;Widen, Elisabeth;Kahonen, Mika;Viikari, Jorma S.;Lehtimaki, Terho;Vollenweider, Peter;Bonnelykke, Klaus;Bisgaard, Hans;Mook-Kanamori, Dennis O.;Hofman, Albert;Rivadeneira, Fernando;Uitterlinden, Andre G.;Pisinger, Charlotta;Pedersen, Oluf;Power, Christine;Hyppoenen, Elina;Wareham, Nicholas J.;Hakonarson, Hakon;Davies, Eleanor;Walker, Brian R.;Jaddoe, Vincent W. V.;Jaervelin, Marjo-Riitta;Grant, Struan F. A.;Vaag, Allan A.;Lawlor, Debbie A.;Frayling, Timothy M.;Smith, George Davey;Morris, Andrew P.;Ong, Ken K.;Felix, Janine F.;Timpson, Nicholas J.;Perry, John R. B.;Evans, David M.;McCarthy, Mark I.;Freathy, Rachel M.
通讯作者：
Freathy, Rachel M.
DOI：
10.1375/twin.4.5.400
发表时间：
2001-10-01
期刊：
Twin research : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Johansson, M;Rasmussen, F
通讯作者：
Rasmussen, F
影响因子：
5.7
作者：
Ollikainen M;Ismail K;Gervin K;Kyllönen A;Hakkarainen A;Lundbom J;Järvinen EA;Harris JR;Lundbom N;Rissanen A;Lyle R;Pietiläinen KH;Kaprio J
通讯作者：
Kaprio J
影响因子：
7.1
作者：
ROWLAND, ML
通讯作者：
ROWLAND, ML
影响因子：
3.7
作者：
Relton CL;Groom A;St Pourcain B;Sayers AE;Swan DC;Embleton ND;Pearce MS;Ring SM;Northstone K;Tobias JH;Trakalo J;Ness AR;Shaheen SO;Davey Smith G
通讯作者：
Davey Smith G