Detection and widespread distribution of Chlamydia pneumoniae in the vascular system and its possible implications.
Detection and widespread distribution of Chlamydia pneumoniae in the vascular system and its possible implications.
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肺炎衣原体在血管系统中的检测和广泛分布及其可能的影响。
DOI：
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发表时间：
1996
影响因子：
3.4
通讯作者：
D. Taylor
中科院分区：
文献类型：
--
作者：
G. Ong;B. Thomas;A. Mansfield;B. Davidson;D. Taylor
目的：检测动脉粥样硬化血管组织中肺炎衣原体DNA。方法：一个现有的聚合酶链反应（PCR）检测和免疫荧光染色与针对肺炎衣原体的单克隆抗体的修改被用来检测肺炎衣原体。对32例接受腹主动脉瘤修复术的患者的标本进行了检查。还检查了来自六个肝移植供体的表面上正常的血管组织以进行比较。共检查了这38例受试者（年龄范围36-85岁）的43支血管。研究结果：在25例动脉瘤中的11例（44%）、9例髂动脉中的5例（55%）、5例股动脉中的2例（40%）和2例髂静脉中的1例中检测到肺炎衣原体。免疫荧光染色支持阳性PCR结果中的12例中的3例使用。总体而言，在14例（44%）接受血管手术的患者和3例（50%）供体的动脉中检测到肺炎衣原体。结论：这项研究是英国首次在动脉粥样硬化血管中发现肺炎衣原体，并且该生物体最常出现在表现出慢性炎症变化的血管中的趋势表明，在各种形式的动脉炎中寻找它们也可能是有益的。
AIMS: To attempt to detect Chlamydia pneumoniae DNA in atheromatous vascular tissue. METHODS: A modification of an existing polymerase chain reaction (PCR) assay and immunofluorescence staining with a monoclonal antibody directed against C pneumoniae were used to detect C pneumoniae. Specimens from 32 patients undergoing abdominal aortic aneurysm repair were examined. Vascular tissue, ostensibly normal, from six liver transplant donors was also examined for comparison. Altogether, 43 vessels from these 38 subjects (age range 36-85 years) were examined. RESULTS: C pneumoniae was detected in 11 (44%) of 25 aortas, five (55%) of nine iliac arteries, two (40%) of five femoral arteries, and one of two iliac veins. Immunofluorescence staining supported positive PCR results in three of 12 cases in which it was used. Overall, C pneumoniae was detected in the arteries of 14 (44%) of the patients undergoing vascular surgery and three (50%) of the donors. CONCLUSIONS: This study is the first in the UK in which C pneumoniae organisms have been found in atherosclerotic vessels and the tendency for the organisms to be present most often in such vessels exhibiting chronic inflammatory changes suggests that a search for them in various forms of arteritis may also be rewarding.
DOI：
10.1161/01.atv.13.10.1501
发表时间：
1993-10-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
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作者：
KUO, CC;GOWN, AM;GRAYSTON, JT
通讯作者：
GRAYSTON, JT
冠状动脉脂肪条纹和粥样斑块中肺炎衣原体的检测。
DOI：
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发表时间：
1992
期刊：
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
影响因子：
--
作者：
Shor,A;Kuo,CC;Patton,DL
通讯作者：
Patton,DL
肺炎衣原体菌株 TWAR 抗体和血管造影显示冠状动脉疾病。
DOI：
10.1161/01.atv.11.3.547
发表时间：
1991
期刊：
Arteriosclerosis and thrombosis : a journal of vascular biology
影响因子：
--
作者：
Thom,DH;Wang,SP;Grayston,JT;Siscovick,DS;Stewart,DK;Kronmal,RA;Weiss,NS
通讯作者：
Weiss,NS