Intelligent Nucleic Acid Functionalized Dual-Responsive Gold Nanoflare: Logic-Gate Nanodevice Visualized by Single-Nanoparticle Imaging
Intelligent Nucleic Acid Functionalized Dual-Responsive Gold Nanoflare: Logic-Gate Nanodevice Visualized by Single-Nanoparticle Imaging
复制标题
智能核酸功能化双响应金纳米耀斑：单纳米粒子成像可视化的逻辑门纳米器件
DOI：
10.1002/slct.201600018
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发表时间：
2016-03
期刊：
影响因子：
2.1
通讯作者：
Kemin Wang
中科院分区：
文献类型：
--
作者：
Jianbo Liu;Haining Ji;Jin Huang;Li Li;Qing Wang;Xiaohai Yang;Kemin Wang
研制了一种智能核酸功能化双响应金纳米荧光，并通过单纳米颗粒成像技术验证了其异或逻辑响应。将Cy5标记的腺苷适体和DNA分子信标修饰在金纳米片表面，成功实现了基于腺苷适体结合诱导荧光猝灭和cDNA结合触发荧光恢复的异或逻辑门操作。在单纳米粒子水平上系统地研究了它们的物理化学性质、浓度依赖性荧光变化和逻辑门响应。单逻辑门成像表明，需要更大的输入来产生足以进行单纳米颗粒分析的变化，并且逻辑门可以很好地用于刺激的生物过程。这一工作对纳米器件的制备和单粒子水平的DNA计算机的研究具有重要意义。
An intelligent nucleic acid functionalized dual-responsive gold nanoflare was developed, and its exclusive-OR (XOR) logic response was demonstrated by single-nanoparticle imaging technology. Cy5 labelled adenosine aptamer and DNA molecule beacon were modified on the surface of gold nanoflares and consequence XOR logic-gate operation was successfully achieved based on adenosine aptamer binding induced fluorescence quenching and cDNA bind triggered fluorescence recovery. Their photophysical properties, concentration-dependent fluorescence variation and logic-gate response were systematically studied at the single-nanoparticle level. Single logic gate imaging demonstrated that a larger input was required to produce a change sufficient for single-nanoparticle analysis, and the logic gate can be well used for a stimulated biologic process. This work will be significant in the future fabrication of nanodevices and DNA computer at single-particle level.
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