Coffee, alcohol, smoking, physical activity and QT interval duration: results from the Third National Health and Nutrition Examination Survey.
Coffee, alcohol, smoking, physical activity and QT interval duration: results from the Third National Health and Nutrition Examination Survey.
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DOI：
10.1371/journal.pone.0017584
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发表时间：
2011-02-28
期刊：
影响因子：
3.7
通讯作者：
Guallar E
中科院分区：
文献类型：
--
作者：
Zhang Y;Post WS;Dalal D;Blasco-Colmenares E;Tomaselli GF;Guallar E
心电图QT间期缩短与室性心律失常和心源性猝死的风险增加相关。然而，对于可改变的因素（如咖啡摄入、吸烟、饮酒和体力活动）对QT间期持续时间的影响存在很大的不确定性。我们研究了第三次全国健康和营养调查（NHANES III，1988-1994）的7795名男性和女性。根据标准12导联心电图测量基线QT间期。咖啡和茶的摄入量，饮酒量，过去一个月的休闲体育活动，以及一生的吸烟习惯，在家庭访谈中使用经过验证的问卷进行确定。在完全校正的模型中，每天饮用≥6杯咖啡的参与者与不饮用任何咖啡的参与者相比，QT间期的平均差异分别为-1.2 ms（95% CI-4.4至2.0）和-2.0 ms（-11.2至7.3）。目前吸烟者与从不吸烟者的QT间期平均差异为1.2 ms（-0.6至2.9），而每周饮酒≥7杯的参与者与不饮酒者的QT间期平均差异为1.8 ms（-0.5至4.0）。与非饮酒者或无饮酒者相比，年龄、种族/民族和RR间期校正的平均QT间期差异分别为2.8 ms（0.4 - 5.3）和4.0 ms（1.6 - 6.4）。女性的相应差异为1.1（-2.9至5.2）和1.7 ms（-2.3至5.7）。最后，最高与最低总体力活动类别之间QT间期的平均差异为−0.8 ms（−3.0至1.4）。在男性中，酗酒与较长的QT间期相关，但在女性中则无关。QT间期与其他可改变的因素无关，包括咖啡和茶的摄入、吸烟和体力活动。
Abnormalities in the electrocardiographic QT interval duration have been associated with an increased risk of ventricular arrhythmias and sudden cardiac death. However, there is substantial uncertainty about the effect of modifiable factors such as coffee intake, cigarette smoking, alcohol consumption, and physical activity on QT interval duration. We studied 7795 men and women from the Third National Health and Nutrition Survey (NHANES III, 1988–1994). Baseline QT interval was measured from the standard 12-lead electrocardiogram. Coffee and tea intake, alcohol consumption, leisure-time physical activities over the past month, and lifetime smoking habits were determined using validated questionnaires during the home interview. In the fully adjusted model, the average differences in QT interval comparing participants drinking ≥6 cups/day to those who did not drink any were −1.2 ms (95% CI −4.4 to 2.0) for coffee, and −2.0 ms (−11.2 to 7.3) for tea, respectively. The average differences in QT interval duration comparing current to never smokers was 1.2 ms (−0.6 to 2.9) while the average difference in QT interval duration comparing participants drinking ≥7 drinks/week to non-drinkers was 1.8 ms (−0.5 to 4.0). The age, race/ethnicity, and RR-interval adjusted differences in average QT interval duration comparing men with binge drinking episodes to non-drinkers or drinkers without binge drinking were 2.8 ms (0.4 to 5.3) and 4.0 ms (1.6 to 6.4), respectively. The corresponding differences in women were 1.1 (−2.9 to 5.2) and 1.7 ms (−2.3 to 5.7). Finally, the average differences in QT interval comparing the highest vs. the lowest categories of total physical activity was −0.8 ms (−3.0 to 1.4). Binge drinking was associated with longer QT interval in men but not in women. QT interval duration was not associated with other modifiable factors including coffee and tea intake, smoking, and physical activity.
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影响因子：
2.8
作者：
Agarwal, Shikhar
通讯作者：
Agarwal, Shikhar
DOI：
10.1002/art.22762
发表时间：
2007-06-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Choi, Hyon K.;Curhan, Gary
通讯作者：
Curhan, Gary
影响因子：
4.1
作者：
Ammar, R;Song, JC;White, CM
通讯作者：
White, CM
影响因子：
5.9
作者：
FANKUSHEN, D;RASKIN, D;WALLACH, S
通讯作者：
WALLACH, S
DOI：
10.1097/01.hjr.0000173110.21851.a9
发表时间：
2005-08-01
影响因子：
--
作者：
Benoit, SR;Mendelsohn, AB;Graham, DJ
通讯作者：
Graham, DJ