Clinical applications of epigenetics in cardiovascular disease: the long road ahead.
Clinical applications of epigenetics in cardiovascular disease: the long road ahead.
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DOI：
10.1016/j.trsl.2014.04.004
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Arnett DK
中科院分区：
文献类型：
--
作者：
Aslibekyan S;Claas SA;Arnett DK
表观遗传过程，定义为基因表达的可遗传变化，而不改变DNA序列，已成为心血管疾病研究的一个有前途的领域。表观遗传学信息超越了基因型本身的信息，由于表观基因组与环境的相互作用，表观遗传学信息提供了心血管疾病发病机制的综合病因学描述。表观遗传生物标志物包括DNA甲基化、组蛋白修饰和基于RNA的机制，它们都是可修饰的和细胞类型特异性的，这使得它们不仅对环境有反应，而且是药物开发的有吸引力的靶点。然而，围绕心血管表观遗传学可能应用的热情目前超过了现有的证据。本文综述了表观遗传学改变与心血管疾病之间的联系，强调了心血管表观遗传学的转化潜力与临床现实之间的差距。
Epigenetic processes, defined as heritable changes in gene expression that occur without changes to the DNA sequence, have emerged as a promising area of cardiovascular disease research. Epigenetic information transcends that of the genotype alone, and provides for an integrated etiologic picture of cardiovascular disease pathogenesis because of the interaction of the epigenome with the environment. Epigenetic biomarkers, which include DNA methylation, histone modifications, and RNA-based mechanisms, are both modifiable and cell-type specific, which makes them not only responsive to the environment, but also an attractive target for drug development. However, the enthusiasm surrounding possible applications of cardiovascular epigenetics currently outpaces available evidence. In this review, we synthesize the evidence linking epigenetic changes with cardiovascular disease, emphasizing the gap between the translational potential and the clinical reality of cardiovascular epigenetics.
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DOI：
10.1097/ede.0b013e31824523f0
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bind MA;Baccarelli A;Zanobetti A;Tarantini L;Suh H;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
3.7
作者：
Duygu B;Poels EM;da Costa Martins PA
通讯作者：
da Costa Martins PA
影响因子：
64.5
作者：
Anand P;Brown JD;Lin CY;Qi J;Zhang R;Artero PC;Alaiti MA;Bullard J;Alazem K;Margulies KB;Cappola TP;Lemieux M;Plutzky J;Bradner JE;Haldar SM
通讯作者：
Haldar SM
影响因子：
7.3
作者：
Chen, Jhih-Bin;Chern, Ting-Rong;Fang, Jim-Min
通讯作者：
Fang, Jim-Min
影响因子：
4.4
作者：
Almen, Markus Sallman;Jacobsson, Josefin A.;Schioth, Helgi B.
通讯作者：
Schioth, Helgi B.