Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving.
Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving.
复制标题
DOI：
10.1016/j.biopsych.2013.01.003
复制
发表时间：
2013-04-15
影响因子：
10.6
通讯作者：
George, Mark S.
中科院分区：
文献类型：
--
作者：
Li, Xingbao;Hartwell, Karren J.;Owens, Max;LeMatty, Todd;Borckardt, Jeffrey J.;Hanlon, Colleen A.;Brady, Kathleen T.;George, Mark S.
重复性经颅磁刺激(RTMS)可以非侵入性地刺激大脑，并瞬时放大或阻断通过某个区域的行为。我们假设，与假TMS会话相比，在左侧背外侧前额叶皮质(DLPFC)进行单一的高频rTMS会话将减少线索对香烟的渴望。16名没有寻求治疗、尼古丁依赖的参与者被随机分为两组，分别接受真正的高频rTMS(10赫兹，100%静息运动阈值，5秒开启，10秒关闭，15分钟；3000次脉冲)或DLPFC上的主动假TMS(Esham)，两次治疗间隔一周。参与者在rTMS之前和之后接受线索暴露，并在每段线索呈现后对他们的渴望进行评级。刺激左侧DLFPC时，用真实的rTMS，而不是假的，从基线开始显著降低渴求(64.1vs.45.7vs.45.7±6.4，t=2.69，p=0.018)。与中性线索渴求相比，真实TM对线索渴求的影响显著大于Sham TM(12.5±10.4vs.−9.1±10.4；t=2.07，p=0.049)。服用避孕药引起的主观渴求的减少与较高的尼古丁依赖Fagerström测试分数(r=0.58，p=0.031)和较多的每天吸烟(r=0.57，p=0.035)呈正相关。一次左侧DLPFC的高频rTMS(10赫兹)显著减少了尼古丁依赖参与者因吸烟线索引起的主观渴望。需要进一步的研究来探索rTMS作为戒烟辅助手段的使用。
Repetitive transcranial magnetic stimulation (rTMS) can non-invasively stimulate the brain and transiently amplify or block behaviors mediated through a region. We hypothesized that a single high-frequency rTMS session over the left dorsolateral prefrontal cortex (DLPFC) would reduce cue craving for cigarettes compared to a sham TMS session. Sixteen non-treatment seeking, nicotine-dependent participants were randomized to receive either real high-frequency rTMS (10 Hz, 100% resting motor threshold, 5 second-on, 10 second-off for 15 minutes; 3000 pulses) or active sham (eSham) TMS over the DLPFC in two visits with one week between visits. The participants received cue exposure before and after rTMS and rated their craving after each block of cue presentation. Stimulation of the left DLFPC with real, but not sham, rTMS reduced craving significantly from baseline (64.1± 5.9 vs. 45.7±6.4, t = 2.69, p = 0.018). When compared to neutral cue craving, the effect of real TMS on cue craving was significantly greater than the effect of sham TMS (12.5 ±10.4 vs. −9.1±10.4; t = 2.07, p = 0.049). More decreases in subjective craving induced by TMS correlated positively with higher Fagerström Test for Nicotine Dependence (FTND) score (r = 0.58, p = 0.031) and more cigarettes smoked per day (r = 0.57, p = 0.035). One session of high frequency rTMS (10 Hz) of the left DLPFC significantly reduced subjective craving induced by smoking cues in nicotine-dependent participants. Further studies are needed to explore the use of rTMS as an aid to smoking cessation.
登录
查看更多内容
影响因子：
7.7
作者：
Anderson, Berry S.;Kavanagh, Katie;Borckardt, Jeffrey J.;Nahas, Ziad H.;Kose, Samet;Lisanby, Sarah H.;McDonald, William M.;Avery, David;Sackeim, Harold A.;George, Mark S.
通讯作者：
George, Mark S.
影响因子：
10.6
作者：
Bohning, DE;Shastri, A;George, MS
通讯作者：
George, MS
影响因子：
2
作者：
Berardelli, A;Inghilleri, M;Manfredi, M
通讯作者：
Manfredi, M
影响因子：
6
作者：
Amiaz, Revital;Levy, Dino;Zangen, Abraham
通讯作者：
Zangen, Abraham
影响因子：
4.4
作者：
FAGERSTROM, KO
通讯作者：
FAGERSTROM, KO