Deep ancestry of programmed genome rearrangement in lampreys.
Deep ancestry of programmed genome rearrangement in lampreys.
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DOI：
10.1016/j.ydbio.2017.06.032
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发表时间：
2017-09-01
影响因子：
2.7
通讯作者：
Smith JJ
中科院分区：
文献类型：
--
作者：
Timoshevskiy VA;Lampman RT;Hess JE;Porter LL;Smith JJ
在大多数多细胞生物中，基因组的结构和内容在发育过程中得到严格的维持。然而，一些物种已经进化出基因组生物学，允许或需要基因组物理结构和内容的发育调节变化（程序性基因组重排：PGR）。虽然迄今为止调查的所有agnathans（几种盲鳗和一种七鳃鳗：Petromyzon marinus）都显示出大规模PGR的证据，但已知经历PGR的脊椎动物相对较少。为了进一步解决PGR在脊椎动物中的起源问题，我们开发了探针，可以同时跟踪P. marinus和第二种七鳃鳗（Entosphenus tridentatus）中几乎所有被PGR消除的序列。这些比较分析揭示了与PGR相关的保守的亚细胞结构（滞后染色质和微核），并提供了第一个比较胚胎学证据，支持PGR代表了一种古老的、进化稳定的策略，用于调节生殖细胞和体细胞之间固有的发育/遗传冲突。
In most multicellular organisms, the structure and content of the genome is rigorously maintained over the course of development. However some species have evolved genome biologies that permit, or require, developmentally regulated changes in the physical structure and content of the genome (programmed genome rearrangement: PGR). Relatively few vertebrates are known to undergo PGR, although all agnathans surveyed to date (several hagfish and one lamprey: Petromyzon marinus) show evidence of large scale PGR. To further resolve the ancestry of PGR within vertebrates, we developed probes that allow simultaneous tracking of nearly all sequences eliminated by PGR in P. marinus and a second lamprey species (Entosphenus tridentatus). These comparative analyses reveal conserved subcellular structures (lagging chromatin and micronuclei) associated with PGR and provide the first comparative embryological evidence in support of the idea that PGR represents an ancient and evolutionarily stable strategy for regulating inherent developmental/genetic conflicts between germline and soma.
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影响因子：
30.8
作者：
Smith, Jeramiah J.;Kuraku, Shigehiro;Holt, Carson;Sauka-Spengler, Tatjana;Jiang, Ning;Campbell, Michael S.;Yandell, Mark D.;Manousaki, Tereza;Meyer, Axel;Bloom, Ona E.;Morgan, Jennifer R.;Buxbaum, Joseph D.;Sachidanandam, Ravi;Sims, Carrie;Garruss, Alexander S.;Cook, Malcolm;Krumlauf, Robb;Wiedemann, Leanne M.;Sower, Stacia A.;Decatur, Wayne A.;Hall, Jeffrey A.;Amemiya, Chris T.;Saha, Nil R.;Buckley, Katherine M.;Rast, Jonathan P.;Das, Sabyasachi;Hirano, Masayuki;McCurley, Nathanael;Guo, Peng;Rohner, Nicolas;Tabin, Clifford J.;Piccinelli, Paul;Elgar, Greg;Ruffier, Magali;Aken, Bronwen L.;Searle, Stephen M. J.;Muffato, Matthieu;Pignatelli, Miguel;Herrero, Javier;Jones, Matthew;Brown, C. Titus;Chung-Davidson, Yu-Wen;Nanlohy, Kaben G.;Libants, Scot V.;Yeh, Chu-Yin;McCauley, David W.;Langeland, James A.;Pancer, Zeev;Fritzsch, Bernd;de Jong, Pieter J.;Zhu, Baoli;Fulton, Lucinda L.;Theising, Brenda;Flicek, Paul;Bronner, Marianne E.;Warren, Wesley C.;Clifton, Sandra W.;Wilson, Richard K.;Li, Weiming
通讯作者：
Li, Weiming
DOI：
10.1007/bf02358846
发表时间：
1975-01-01
期刊：
EXPERIENTIA
影响因子：
--
作者：
ROBINSON, ES;POTTER, IC;ATKIN, NB
通讯作者：
ATKIN, NB
DOI：
10.1073/pnas.0902358106
发表时间：
2009-07-07
影响因子：
11.1
作者：
Smith, Jeramiah J.;Antonacci, Francesca;Amemiya, Chris T.
通讯作者：
Amemiya, Chris T.
影响因子：
9.2
作者：
Smith, Jeramiah J.;Baker, Carl;Amemiya, Chris T.
通讯作者：
Amemiya, Chris T.
影响因子：
4.5
作者：
Timoshevskiy VA;Herdy JR;Keinath MC;Smith JJ
通讯作者：
Smith JJ