Dynamic peripheral nerve metabolic and vascular responses to exsanguination.
Dynamic peripheral nerve metabolic and vascular responses to exsanguination.
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动态周围神经代谢和血管对失血的反应。
DOI：
10.1152/ajpendo.1987.253.4.e349
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Low,PA
中科院分区：
文献类型：
--
作者：
Takeuchi,M;Low,PA
我们研究了在3-12分钟内放血约三分之一的大鼠血容量对大鼠坐骨神经能量代谢和血流量的动态影响。神经高能磷酸盐化合物保持相对良好。缓慢放血时，无氧代谢受到适度刺激，葡萄糖储备略有增加。这些发现表明，当压力，因为显着的失血，代偿机制，推测肾上腺交感神经介导的，是有效的体内。我们同时记录了神经血流量（NBF）、神经内膜氧分压和平均动脉压; NBF与血压（BP）在很宽的BP范围内呈线性相关，证实NBF不显著自动调节。神经内膜进行氧交换，表明周围神经微血管是生理营养的。NBF的下降先于BP，且下降速度快于BP，表明它是一个电容性系统。神经也适应了氧气供应的下降，可能是通过减少氧气消耗。这样一个系统的生理影响进行了讨论。
We studied the dynamic effects of exsanguination of approximately one-third of rat blood volume over 3-12 min on energy metabolism and blood flow in rat sciatic nerves. Nerve high-energy phosphate compounds were relatively well maintained. There was a modest stimulation of anaerobic metabolism at slow rates of exsanguination, and glucose stores were slightly increased. These findings indicate that when stressed because of significant blood loss, compensatory mechanisms, presumably adrenosympathetic mediated, are effective in vivo. We recorded nerve blood flow (NBF), endoneurial oxygen tension, and mean arterial pressure simultaneously; NBF was linearly related to blood pressure (BP) over a wide range of BPs, confirming that NBF does not significantly autoregulate. Endoneurium underwent oxygen-exchange, indicating that peripheral nerve microvasculature is physiologically nutritive. NBF fell before and at a faster rate than BP, indicating that it is a capacitive system. Nerves also adapted to declining oxygen supplies, presumably by reducing their oxygen consumption. The physiological implications of such a system are discussed.
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