Transfer RNA-derived small RNAs in Plants

Transfer RNA-derived small RNAs in Plants
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在植物中转移 RNA 衍生的小 RNA

DOI:
10.1007/s11427-017-9167-5
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发表时间:
2017-11
期刊:
Sci China Life Sci
影响因子:
--
通讯作者:
Zhicheng Dong
Zhicheng Dong
中科院分区:
其他
文献类型:
--
作者:
Lei Zhu;David W. Ow;Zhicheng Dong

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这些18 - 40个核苷酸(nt)的转移RNA衍生的小RNA (tsrna)不是随机降解产物,而是由古细菌、细菌和真核生物中的pre-RNA或成熟trna特异性产生的RNA物种。最近来自动物系统的研究表明,tsRNAs是在转录和/或转录后水平调节基因表达的重要非编码rna。它们参与多种生物学过程,如细胞增殖、肿瘤发生、应激反应和代际表观遗传。本文将对高等植物中tsRNAs的发现、生物发生及功能进行综述。此外,本文还对来自低等植物的tsRNAs进行了分析。
Rather than random degradation products, the 18 to 40 nucleotides (nt) transfer RNA-derived small RNAs (tsRNAs) are RNA species generated specifically from pre-RNAs or mature tRNAs in archaea, bacteria and eukaryotes. Recent studies from animal systems have shown that tsRNAs are important non-coding RNAs that regulate gene expression at the transcriptional and/or post-transcriptional levels. They are involved in various biological processes, such as cell proliferation, tumor genesis, stress response and intergenerational epigenetic inheritance. In this review, we will summarize the discovery, biogenesis, and function of tsRNAs in higher plants. In addition, analysis on tsRNAs from lower plants is shown.
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