Estradiol acts in the medial preoptic area, arcuate nucleus, and dorsal raphe nucleus to reduce food intake in ovariectomized rats.
Estradiol acts in the medial preoptic area, arcuate nucleus, and dorsal raphe nucleus to reduce food intake in ovariectomized rats.
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DOI：
10.1016/j.yhbeh.2011.03.009
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发表时间：
2011-06
影响因子：
3.5
通讯作者：
Eckel, Lisa A.
中科院分区：
文献类型：
--
作者：
Santollo, Jessica;Torregrossa, Ann-Marie;Eckel, Lisa A.
关键词：
雌二醇（E2）对多种物种的食物摄入量具有抑制作用。虽然令人信服的证据表明，中央，而不是外周，雌激素受体（ER）介导这种影响，确切的大脑区域参与尚未最终确定。为了鉴定足以产生E2厌食作用的脑区，在切除卵巢的大鼠的下丘脑和中脑内的多个脑区中，在急性、单侧、微量输注溶剂和两种剂量（0.25和2.5 μg）的水溶性形式的E2后，监测食物摄入48小时。在内侧视前区（MPOA）、弓状核（ARC）和中缝背核（DRN）中观察到E2给药后24小时摄食量的剂量相关性减少。在前两个脑区，大剂量的E2也减少了4小时的摄食量。然而，在室旁核、下丘脑外侧核或腹内侧核给予类似的E2并不影响食物摄入。这些数据表明，E2-反应神经元内的MPOA，ARC，和DRN参与雌激素控制的食物摄入量，并提供特定的脑区，为未来的调查的细胞机制雌二醇的促雌激素作用。
Estradiol (E2) exerts an inhibitory effect on food intake in a variety of species. While compelling evidence indicates that central, rather than peripheral, estrogen receptors (ERs) mediate this effect, the exact brain regions involved have yet to be conclusively identified. In order to identify brain regions that are sufficient for E2's anorectic effect, food intake was monitored for 48 h following acute, unilateral, microinfusions of vehicle and two doses (0.25 and 2.5 μg) of a water-soluble form of E2 in multiple brain regions within the hypothalamus and midbrain of ovariectomized rats. Dose-related decreases in 24-h food intake were observed following E2 administration in the medial preoptic area (MPOA), arcuate nucleus (ARC), and dorsal raphe nucleus (DRN). Within the former two brain areas, the larger dose of E2 also decreased 4-h food intake. Food intake was not influenced, however, by similar E2 administration in the paraventricular nucleus, lateral hypothalamus, or ventromedial nucleus. These data suggest that E2-responsive neurons within the MPOA, ARC, and DRN participate in the estrogenic control of food intake and provide specific brain areas for future investigations of the cellular mechanism underlying estradiol's anorexigenic effect.
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