Alternaria alternata Accelerates Loss of Alveolar Macrophages and Promotes Lethal Influenza A Infection.
Alternaria alternata Accelerates Loss of Alveolar Macrophages and Promotes Lethal Influenza A Infection.
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DOI：
10.3390/v12090946
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发表时间：
2020-08-27
期刊：
影响因子：
--
通讯作者：
Rosenberg HF
中科院分区：
文献类型：
--
作者：
Percopo CM;Ma M;Mai E;Redes JL;Kraemer LS;Minai M;Moore IN;Druey KM;Rosenberg HF
长期吸入真菌和真菌成分与呼吸系统疾病的发生有关，尽管它们在急性呼吸道病毒感染发病机制中的作用仍不清楚。在这里，我们评估炎症病理诱导的普遍存在的真菌，互隔交链孢菌的滤液，反复管理，其对感染A型流感的易感性的影响。我们之前已经证明了A.在鼻粘膜上接种alternata导致野生型小鼠对甲型流感亚致死接种物的易感性增加。这里我们证明了A. alternata诱导的增强甲型流感病毒感染不依赖于真菌丝氨酸蛋白酶或核糖核酸酶活性。用A.在病毒感染之前，对链格孢霉的感染导致促炎性细胞因子、嗜中性粒细胞募集和肺泡巨噬细胞的损失，其程度基本上超过了单独响应甲型流感感染所观察到的程度。同时给予免疫调节性植物乳杆菌，这是一种以前显示的限制气道中病毒诱导的炎症的策略，阻断了夸大的致死反应。这些观察结果促进了对严重流感感染的更好理解，对持续暴露于霉菌和真菌的个体具有潜在的临床意义。
Chronic inhalation of fungi and fungal components has been linked to the development of respiratory disorders, although their role with respect to the pathogenesis of acute respiratory virus infection remains unclear. Here, we evaluate inflammatory pathology induced by repetitive administration of a filtrate of the ubiquitous fungus, Alternaria alternata, and its impact on susceptibility to infection with influenza A. We showed previously that A. alternata at the nasal mucosae resulted in increased susceptibility to an otherwise sublethal inoculum of influenza A in wild-type mice. Here we demonstrate that A. alternata-induced potentiation of influenza A infection was not dependent on fungal serine protease or ribonuclease activity. Repetitive challenge with A. alternata prior to virus infection resulted proinflammatory cytokines, neutrophil recruitment, and loss of alveolar macrophages to a degree that substantially exceeded that observed in response to influenza A infection alone. Concomitant administration of immunomodulatory Lactobacillus plantarum, a strategy shown previously to limit virus-induced inflammation in the airways, blocked the exaggerated lethal response. These observations promote an improved understanding of severe influenza infection with potential clinical relevance for individuals subjected to continuous exposure to molds and fungi.
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DOI：
10.1016/j.jaip.2016.01.008
发表时间：
2016-05
期刊：
The journal of allergy and clinical immunology. In practice
影响因子：
--
作者：
Baxi SN;Portnoy JM;Larenas-Linnemann D;Phipatanakul W;Environmental Allergens Workgroup
通讯作者：
Environmental Allergens Workgroup
影响因子：
5.2
作者：
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通讯作者：
Lawrence CB
影响因子：
24.3
作者：
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通讯作者：
Barbry, Pascal
影响因子：
5.4
作者：
Denis, Olivier;Vincent, Muriel;Huygen, Kris
通讯作者：
Huygen, Kris
DOI：
10.1164/rccm.201012-2036oc
发表时间：
2011-07-15
影响因子：
24.7
作者：
Huang, Fang-Fang;Barnes, Peter F.;Shams, Homayoun
通讯作者：
Shams, Homayoun