A common structure underlies low-frequency cortical dynamics in movement, sleep, and sedation.
A common structure underlies low-frequency cortical dynamics in movement, sleep, and sedation.
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DOI：
10.1016/j.neuron.2014.07.022
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发表时间：
2014-09-03
期刊：
影响因子：
16.2
通讯作者：
Jackson, Andrew
中科院分区：
文献类型：
--
作者：
Hall, Thomas M.;de Carvalho, Felipe;Jackson, Andrew
上肢运动通常由规则的子运动组成，并且在运动皮层中已经发现了1至4 Hz之间的子运动频率的神经相关性。运动的时间分布通常被认为是由外在因素，如肢体生物力学和反馈延迟，但另一种可能性是，内在的节奏有助于低频率的行为。我们使用多电极记录在猴子执行等距运动任务，揭示锁定子运动的初级运动皮层的周期性活动，以及运动前皮层的明显振荡。在氯胺酮镇静和自然睡眠期间，皮层活动经历了类似的周期，并在各个区域之间变得同步。由于相同的皮质动力学耦合到子运动，也观察到在没有行为的情况下，我们的结论是，运动网络控制上肢表现出内在的周期性在子运动频率，反映在速度曲线的运动。局部场电位（LFP）和神经放电的相位锁定的子运动学可以解码从面积速度的LFP轨迹相同的动态模式，在自由达到，睡眠和镇静运动回路的内在周期性强加的行为的时间结构霍尔等。发现猴子运动皮层中常见的3 Hz振荡解释了睡眠和镇静期间的运动速度曲线和慢波活动。这些结果揭示了内在网络动力学如何塑造上肢行为。
Upper-limb movements are often composed of regular submovements, and neural correlates of submovement frequencies between 1 and 4 Hz have been found in the motor cortex. The temporal profile of movements is usually assumed to be determined by extrinsic factors such as limb biomechanics and feedback delays, but another possibility is that an intrinsic rhythmicity contributes to low frequencies in behavior. We used multielectrode recordings in monkeys performing an isometric movement task to reveal cyclic activity in primary motor cortex locked to submovements, and a distinct oscillation in premotor cortex. During ketamine sedation and natural sleep, cortical activity traversed similar cycles and became synchronized across areas. Because the same cortical dynamics are coupled to submovements and also observed in the absence of behavior, we conclude that the motor networks controlling the upper limb exhibit an intrinsic periodicity at submovement frequencies that is reflected in the speed profile of movements. Local field potentials (LFPs) and neural firing are phase locked to submovements Movement kinematics can be decoded from the areal velocity of LFP trajectories The same dynamic patterns are seen during free reaching, sleep, and sedation An intrinsic periodicity in motor circuits imposes temporal structure on behavior Hall et al. find that a common 3 Hz oscillation in the motor cortex of monkeys explains both the speed profile of movements and slow-wave activity during sleep and sedation. These results reveal how intrinsic network dynamics shape upper-limb behaviors.
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影响因子：
2.5
作者：
Doeringer, JA;Hogan, N
通讯作者：
Hogan, N
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
5.3
作者：
Bradberry, Trent J.;Gentili, Rodolphe J.;Contreras-Vidal, Jose L.
通讯作者：
Contreras-Vidal, Jose L.
影响因子：
2.5
作者：
Jackson, Andrew;Fetz, Eberhard E.
通讯作者：
Fetz, Eberhard E.
影响因子：
2
作者：
Miall, R. C.;Jackson, J. K.
通讯作者：
Jackson, J. K.