Light-regulated translational control of circadian behavior by eIF4E phosphorylation.
Light-regulated translational control of circadian behavior by eIF4E phosphorylation.
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DOI：
10.1038/nn.4010
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发表时间：
2015-06
影响因子：
25
通讯作者：
Sonenberg, Nahum
中科院分区：
文献类型：
--
作者：
Cao, Ruifeng;Gkogkas, Christos G.;de Zavalia, Nuria;Blum, Ian D.;Yanagiya, Akiko;Tsukumo, Yoshinori;Xu, Haiyan;Lee, Choogon;Storch, Kai-Florian;Liu, Andrew C.;Amir, Shimon;Sonenberg, Nahum
昼夜节律(~24小时)时钟不断地受到环境光的干扰(重置)，从而使内源性节律与环境的日常变化同步。光诱导的基因表达被认为是时钟携带的分子机制。信使核糖核酸的翻译是基因表达的关键步骤，但如何在信使核糖核酸的翻译水平上控制时钟携带尚不清楚。在这里，我们报道了光和生物钟调节的MAPK/MNK通路导致小鼠下丘脑视交叉上核(SCN)的帽结合蛋白eIF4E的磷酸化，这是哺乳动物主生物钟的位置。EIF4E的磷酸化特异性地促进了周期(PER)1和2mRNAs的翻译，并增加了基础和可诱导的PER蛋白的丰度，从而促进了生物钟的重置和精确的计时。总之，这些结果强调了光调节翻译控制在生物钟生理学中的关键作用。
The circadian (~24 h) clock is continuously entrained (reset) by ambient light so that endogenous rhythms are synchronized with daily changes in the environment. Light-induced gene expression is thought to be the molecular mechanism underlying clock entrainment. mRNA translation is a key step of gene expression, but how clock entrainment is controlled at the mRNA translation level is not understood. Here we report that a light- and circadian clock-regulated MAPK/MNK pathway leads to phosphorylation of the cap-binding protein eIF4E in the mouse suprachiasmatic nucleus (SCN) of the hypothalamus, the locus of the master circadian clock in mammals. Phosphorylation of eIF4E specifically promotes translation of Period (Per) 1 and 2 mRNAs and increases the abundance of basal and inducible PER proteins, which facilitates circadian clock resetting and precise timekeeping. Together, these results highlight a critical role for light-regulated translational control in the physiology of the circadian clock.
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影响因子：
16.2
作者：
Cao R;Robinson B;Xu H;Gkogkas C;Khoutorsky A;Alain T;Yanagiya A;Nevarko T;Liu AC;Amir S;Sonenberg N
通讯作者：
Sonenberg N
DOI：
10.1073/pnas.1005320107
发表时间：
2010-08-10
影响因子：
11.1
作者：
Furic, Luc;Rong, Liwei;Sonenberg, Nahum
通讯作者：
Sonenberg, Nahum
影响因子：
64.5
作者：
Balsalobre, A;Damiola, F;Schibler, U
通讯作者：
Schibler, U
DOI：
10.1111/ejn.12028
发表时间：
2013-01
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Cao R;Butcher GQ;Karelina K;Arthur JS;Obrietan K
通讯作者：
Obrietan K
影响因子：
4.8
作者：
Favata, MF;Horiuchi, KY;Trzaskos, JM
通讯作者：
Trzaskos, JM