A nomenclature for ligand-gated ion channels.

A nomenclature for ligand-gated ion channels.
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DOI:
10.1016/j.neuropharm.2008.06.063
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发表时间:
2009-01
期刊:
影响因子:
4.7
通讯作者:
Spedding M
Spedding M
中科院分区:
医学2区
文献类型:
--
作者:
Collingridge GL;Olsen RW;Peters J;Spedding M

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参与快速突触传递的配体门控离子通道包括烟碱乙酰胆碱、5-羟色胺3 (5-HT3)、γ-氨基丁酸(GABAA)、甘氨酸、嗜电性谷氨酸和P2X受体家族。对组成这些受体的单个亚基和它们共同组装的受体有一个一致和系统的命名是非常可取的。还需要制定标准,以帮助确定哪些亚基的大量异质组合可以在体外异种表达系统中组装,哪些是已知的,或可能作为体内功能受体存在。这篇短文的目的是总结IUPHAR命名委员会(NC-IUPHAR)在制定试图解决这些问题的建议方面所取得的进展。
The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), γ-aminobutyric acidA (GABAA), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely, to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues.
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发表时间: 1990-08-03
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