Efficacy and Effectiveness of SARS-CoV-2 Vaccines: A Systematic Review and Meta-Analysis.
Efficacy and Effectiveness of SARS-CoV-2 Vaccines: A Systematic Review and Meta-Analysis.
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SARS-CoV-2疫苗的有效性和有效性：系统评价和荟萃分析。
DOI：
10.3390/vaccines10030350
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发表时间：
2022-02-23
期刊：
影响因子：
7.8
通讯作者：
Taha SHN
中科院分区：
文献类型：
--
作者：
Ghazy RM;Ashmawy R;Hamdy NA;Elhadi YAM;Reyad OA;Elmalawany D;Almaghraby A;Shaaban R;Taha SHN
2019冠状病毒病（COVID-19）大流行已威胁到全球健康，并促使需要进行大规模疫苗接种。我们的目的是评估COVID-19疫苗在第一次和第二次接种后预防死亡率和降低发生严重疾病风险的疗效和有效性。从构思到2021年6月28日，我们检索了PubMed、Cochrane、EBSCO、Scopus、ProQuest、Web of Science、WHO-ICTRP和谷歌Scholar。我们纳入了观察性和随机对照试验。使用随机效应模型估计疫苗接种后的综合效力和有效性及其95%置信区间（CI）。在21,567篇筛选文章中，总共有22篇符合定量分析的条件。与未接种疫苗组相比，接种疫苗组在完全接种疫苗后7天和14天的死亡率分别显著降低（OR = 0.10, [95% CI, 0.04-0.27], I2 = 54%）和（OR = 0.46, [95% CI, 0.35-0.61], I2 = 0%）。第二次给药后1周或2周发生严重疾病的概率分别显著降低（or = 0.29 [95% CI, 0.19-0.46], I2 = 25%）和（or = 0.08 [95% CI, 0.03-0.25], I2 = 74%）。第一次和第二次给药后任何时间的感染发生率分别显著降低（OR = 0.14 [95% CI, 0.07-0.4], I2 = 100%）和（OR = 0.179 [95% CI, 0.15-0.19], I2 = 98%）。第2次给药后1周感染发生率显著降低(OR = 0.04, [95% CI （0.01-0.2], I2 = 100%）。meta回归后，疫苗类型和国家是预后的主要预测因素[非mrna类型，ß = 2.99, p = 0.0001；英国国家，ß =−0.75,p = 0.038；美国，ß = 0.8, p = 0.02]。这项研究表明，大多数疫苗具有相当的效力，据称大规模接种疫苗可能有助于结束这次大流行。
The coronavirus disease 2019 (COVID-19) pandemic has threatened global health and prompted the need for mass vaccination. We aimed to assess the efficacy and effectiveness of COVID-19 vaccines to prevent mortality and reduce the risk of developing severe disease after the 1st and 2nd doses. From conception to 28 June 2021, we searched PubMed, Cochrane, EBSCO, Scopus, ProQuest, Web of Science, WHO-ICTRP, and Google Scholar. We included both observational and randomized controlled trials. The pooled vaccine efficacy and effectiveness following vaccination, as well as their 95 percent confidence intervals (CI), were estimated using the random-effects model. In total, 22 of the 21,567 screened articles were eligible for quantitative analysis. Mortality 7 and 14 days after full vaccination decreased significantly among the vaccinated group compared to the unvaccinated group (OR = 0.10, ([95% CI, 0.04–0.27], I2 = 54%) and (OR = 0.46, [95% CI, 0.35–0.61], I2 = 0%), respectively. The probability of having severe disease one or two weeks after 2nd dose decreased significantly (OR = 0.29 [95% CI, 0.19–0.46], I2 = 25%) and (OR = 0.08 [95% CI, 0.03–0.25], I2 = 74%), respectively. The incidence of infection any time after the 1st and 2nd doses diminished significantly (OR = 0.14 [95% CI, 0.07–0.4], I2 = 100%) and (OR = 0.179 [95% CI, 0.15–0.19], I2 = 98%), respectively. Also, incidence of infection one week after 2nd dose decreased significantly, (OR = 0.04, [95% CI (0.01–0.2], I2 = 100%). After meta-regression, the type of vaccine and country were the main predictors of outcome [non-mRNA type, ß = 2.99, p = 0.0001; country UK, ß = −0.75, p = 0.038; country USA, ß = 0.8, p = 0.02]. This study showed that most vaccines have comparable effectiveness, and it is purported that mass vaccination may help to end this pandemic.
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DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
de Wit E;van Doremalen N;Falzarano D;Munster VJ
通讯作者：
Munster VJ
影响因子：
3.7
作者：
Alagoz O;Sethi AK;Patterson BW;Churpek M;Alhanaee G;Scaria E;Safdar N
通讯作者：
Safdar N
影响因子：
5.4
作者：
Chen, Wen-Hsiang;Strych, Ulrich;Bottazzi, Maria Elena
通讯作者：
Bottazzi, Maria Elena
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group