Drug Delivery From Poly(ethylene glycol) Diacrylate Scaffolds Produced by DLC Based Micro‐Stereolithography
Drug Delivery From Poly(ethylene glycol) Diacrylate Scaffolds Produced by DLC Based Micro‐Stereolithography
复制标题
基于 DLC 的微立体光刻技术生产的聚乙二醇二丙烯酸酯支架的药物输送
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
H. Seitz
中科院分区：
文献类型：
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作者：
M. Vehse;Svea Petersen;K. Sternberg;K. Schmitz;H. Seitz
摘要
本研究采用半导体激光固化(DLC)技术制备聚乙二醇二丙烯酸酯(PEGDA)支架。样品支架还负载了乙酰水杨酸(ASS)作为模型药物。将样品浸泡在生理氯化钠溶液中，测试其药物释放特性。我们发现DLC是制备载药聚乙二醇胺支架的一种有用的技术。富集型和类金刚石固化聚乙二醇胺的抗压强度在7~10 Mpa之间，这取决于ASS的浓度。无ASS样品达到14 Mpa。释放实验表明，ASS在最初的猝发释放阶段，在最初的3 小时内释放。
Summary
In this study, the production of poly(ethylene glycol) diacrylate (PEGDA) scaffolds by micro-stereolithography based on diode laser curing (DLC) is demonstrated. Sample scaffolds are also loaded with acetylsalicylic acid (ASS) as model drug. The samples are immersed in physiological NaCl solution and the drug release characteristics are tested. We show that DLC is a useful technique to prepare drug-loaded PEGDA scaffolds. The compressive strength of the enriched and DLC-cured PEGDA is between 7 and 10 MPa, dependent on ASS concentration. ASS free samples reach 14 MPa. The release experiments show an initial burst release phase and the ASS is released within the first 3 hours.
影响因子：
6.2
作者：
S. Leigh;Hamish T. J. Gilbert;Ian A. Barker;J. Becker;S. Richardson;J. Hoyland;J. Covington;A. P. Dove
通讯作者：
S. Leigh;Hamish T. J. Gilbert;Ian A. Barker;J. Becker;S. Richardson;J. Hoyland;J. Covington;A. P. Dove
影响因子：
14
作者：
Fairbanks, Benjamin D.;Schwartz, Michael P.;Bowman, Christopher N.;Anseth, Kristi S.
通讯作者：
Anseth, Kristi S.