Functions of Bacterial tRNA Modifications: From Ubiquity to Diversity.
Functions of Bacterial tRNA Modifications: From Ubiquity to Diversity.
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DOI：
10.1016/j.tim.2020.06.010
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发表时间：
2021-01
影响因子：
15.9
通讯作者：
Jaroch M
中科院分区：
文献类型：
--
作者：
de Crécy-Lagard V;Jaroch M
tRNA中修饰的核苷酸是翻译装置的重要组成部分，但它们在翻译调控过程中的重要性直到最近才被大大忽视。最近的两项突破使我们能够更全面地了解tRNA修饰在细菌生理学中的重要性。一个是鉴定模式生物如大肠杆菌K12中的全套tRNA修饰基因。第二是改进现有的分析工具来监测tRNA修饰模式。tRNA修饰的作用随给定tRNA内的特定修饰和所研究的生物体而变化很大。它们的缺失或减少可导致细胞死亡、多效性表型或没有明显可见的作用。通过将翻译（通过其解码功能）与代谢（通过其生物合成途径）联系起来，tRNA修饰正成为细菌调控工具箱的重要组成部分。
Modified nucleotides in tRNA are critical components of the translation apparatus but their importance in the process of translational regulation had until recently been greatly overlooked. Two breakthroughs have recently allowed to more fully understand the importance of tRNA modifications in bacterial physiology. One is the identification of the full set of tRNA modifications genes in model organisms such as Escherichia coli K12. The second is the improvement of available analytical tools to monitor tRNA modifications patterns. The role of tRNA modifications vary greatly with the specific modification within a given tRNA and with the organism studied. Their absence or reduction can lead to cell death, pleiotropic phenotypes or have no apparent visible effect. By linking translation through their decoding functions to metabolism through their biosynthetic pathways, tRNA modifications are emerging as important components of the bacterial regulatory toolbox.
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影响因子：
7
作者：
Bar-Yaacov D;Mordret E;Towers R;Biniashvili T;Soyris C;Schwartz S;Dahan O;Pilpel Y
通讯作者：
Pilpel Y
独特的 tRNA 基因谱表明深海共生螺原体的反密码子中缺乏核苷酸修饰。
影响因子：
14.9
作者：
Wang Y;Zhu FC;He LS;Danchin A
通讯作者：
Danchin A
影响因子：
2.8
作者：
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通讯作者：
Wen, Zezhang T.
影响因子：
10.7
作者：
Diwan GD;Agashe D
通讯作者：
Agashe D
影响因子：
4.1
作者：
Bar-Yaacov, Dan;Pilpel, Yitzhak;Dahan, Orna
通讯作者：
Dahan, Orna