Environmental risk factors for dementia: a systematic review.
Environmental risk factors for dementia: a systematic review.
复制标题
DOI：
10.1186/s12877-016-0342-y
复制
发表时间：
2016-10-12
期刊：
影响因子：
4.1
通讯作者：
Russ TC
中科院分区：
文献类型：
--
作者：
Killin LO;Starr JM;Shiue IJ;Russ TC
降低痴呆症风险是一个重要的和不断增长的公共卫生优先事项。虽然已经确定了痴呆症的某些可改变的风险因素，但仍然存在相当大比例的无法解释的风险。有证据表明，环境风险因素可以解释这种风险的一部分。因此，我们提出了第一个全面的系统评价痴呆症的环境危险因素。我们搜索了PubMed和Web of Science数据库（从成立到2016年1月）、评论文章书目以及与公开环境数据相关的文章。如果文章检查了环境风险因素与痴呆症之间的关联，则将其纳入。排除了具有其他结果（例如认知）的研究、暴露的生理测量、病例研究、动物研究和营养研究。数据是从个别研究中提取的，这些研究反过来又对方法质量进行了评价。评估了所确定的每个风险因素的总体证据的强度和一致性。我们筛选了4784项研究，其中60项纳入综述。风险因素分为六类：空气质量、有毒重金属、其他金属、其他微量元素、与职业有关的暴露和各种环境因素。很少有研究采用生命过程的方法。至少有适度的证据表明以下风险因素：空气污染;铝;硅;硒;杀虫剂;维生素D缺乏症;以及电场和磁场。研究的规模和质量差异很大，因此我们必须谨慎地得出结论。然而，这项广泛的综述表明，未来的研究可能会集中在痴呆症的环境风险因素的简短列表上。此外，需要进一步的强有力的，纵向研究与环境暴露的重复测量，以确认这些关联。
Dementia risk reduction is a major and growing public health priority. While certain modifiable risk factors for dementia have been identified, there remains a substantial proportion of unexplained risk. There is evidence that environmental risk factors may explain some of this risk. Thus, we present the first comprehensive systematic review of environmental risk factors for dementia. We searched the PubMed and Web of Science databases from their inception to January 2016, bibliographies of review articles, and articles related to publically available environmental data. Articles were included if they examined the association between an environmental risk factor and dementia. Studies with another outcome (for example, cognition), a physiological measure of the exposure, case studies, animal studies, and studies of nutrition were excluded. Data were extracted from individual studies which were, in turn, appraised for methodological quality. The strength and consistency of the overall evidence for each risk factor identified was assessed. We screened 4784 studies and included 60 in the review. Risk factors were considered in six categories: air quality, toxic heavy metals, other metals, other trace elements, occupational-related exposures, and miscellaneous environmental factors. Few studies took a life course approach. There is at least moderate evidence implicating the following risk factors: air pollution; aluminium; silicon; selenium; pesticides; vitamin D deficiency; and electric and magnetic fields. Studies varied widely in size and quality and therefore we must be circumspect in our conclusions. Nevertheless, this extensive review suggests that future research could focus on a short list of environmental risk factors for dementia. Furthermore, further robust, longitudinal studies with repeated measures of environmental exposures are required to confirm these associations.
登录
查看更多内容
影响因子：
4.9
作者：
Chen R;Wilson K;Chen Y;Zhang D;Qin X;He M;Hu Z;Ma Y;Copeland JR
通讯作者：
Copeland JR
影响因子：
14
作者：
Brookmeyer, Ron;Johnson, Elizabeth;Arrighi, H. Michael
通讯作者：
Arrighi, H. Michael
影响因子：
5.7
作者：
Bermejo, F;Gabriel, R;Anderson, DW
通讯作者：
Anderson, DW
影响因子：
2.4
作者：
Annweiler, C.;Rolland, Y.;Beauchet, O.
通讯作者：
Beauchet, O.
DOI：
10.1111/j.1751-908x.2001.tb00999.x
发表时间：
2001-01-01
期刊：
GEOSTANDARDS NEWSLETTER-THE JOURNAL OF GEOSTANDARDS AND GEOANALYSIS
影响因子：
--
作者：
Civita, M;Fiorucci, A;Miè, R
通讯作者：
Miè, R