Phase Separation in Cell Division.
Phase Separation in Cell Division.
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DOI：
10.1016/j.molcel.2020.08.007
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发表时间：
2020-10-01
期刊：
影响因子：
16
通讯作者：
Torres JZ
中科院分区：
文献类型：
--
作者：
Ong JY;Torres JZ
Cell division requires the assembly and organization of a microtubule spindle for the proper separation of chromosomes in mitosis and meiosis. Phase separation is an emerging paradigm for understanding spatial and temporal regulation of a variety of cellular processes, including cell division. Phase-separated condensates have been recently discovered at many structures during cell division as a possible mechanism for properly localizing, organizing, and activating proteins involved in cell division. Here, we review how these condensates play roles in regulating microtubule density and organization, spindle assembly and function, and activating some of the key players in cell division. We conclude with perspectives on areas of future research for this exciting and rapidly advancing field. The process of cell division requires spatial and temporal control over microtubule-associated proteins and their regulatory factors to promote the assembly and function of the microtubule pindle. In this review, Ong and Torres describe the role of phase separation in cell division and in coordinating and organizing the assembly of cell division factors and the microtubule spindle.
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