The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.
The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.
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DOI：
10.1016/j.cortex.2021.04.016
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Kennedy KM
中科院分区：
文献类型：
--
作者：
Hoagey DA;Lazarus LTT;Rodrigue KM;Kennedy KM
即使在健康的老龄化过程中，血管风险因素也会在精神上影响认知，其中执行功能（EF）尤其脆弱。额顶叶白色物质（WM）连接部分支持EF，可能对血管风险特别敏感。在这里，我们利用结构方程模型在184名健康成年人（年龄20-94岁），以测试的假设：1）额顶叶WM微结构介导的年龄对EF的影响; 2）高血压（BP）和白色高信号（WMH）负担影响这种关联。所有参与者都接受了全面的认知和神经心理学测试，包括处理速度、执行功能测试（重点是需要切换和抑制的任务），并完成了MRI扫描，其中包括用于半自动量化白色物质高强度负荷的FLAIR成像和用于纤维束成像的扩散加权成像。结构方程模型指定年龄（作为连续变量）和血压预测内道WMH负担和分数各向异性预测执行功能和处理速度。结果表明，胼胝体前部的额顶白色物质、上级纵束和额枕下束（而不是皮质脊髓束）介导了年龄与EF之间的关联。此外，收缩压升高和这些白色物质束内的白色物质高强度负荷导致白色物质健康状况恶化，并且是年龄-大脑-行为关联的重要因素。这些研究结果表明，随着年龄的增长，BP和WMH的负担都增加，这可能与白色物质连接的退化有关，反过来又会对我们的执行功能产生负面影响。
Even within healthy aging, vascular risk factors can detrimentally influence cognition, with executive functions (EF) particularly vulnerable. Fronto-parietal white matter (WM) connectivity in part, supports EF and may be particularly sensitive to vascular risk. Here, we utilized structural equation modeling in 184 healthy adults (aged 20–94 years of age) to test the hypotheses that: 1) fronto-parietal WM microstructure mediates age effects on EF; 2) higher blood pressure (BP) and white matter hyperintensity (WMH) burden influences this association. All participants underwent comprehensive cognitive and neuropsychological testing including tests of processing speed, executive function (with a focus on tasks that require switching and inhibition) and completed an MRI scanning session that included FLAIR imaging for semi-automated quantification of white matter hyperintensity burden and diffusion-weighted imaging for tractography. Structural equation models were specified with age (as a continuous variable) and blood pressure predicting within-tract WMH burden and fractional anisotropy predicting executive function and processing speed. Results indicated that fronto-parietal white matter of the genu of the corpus collosum, superior longitudinal fasciculus, and the inferior frontal occipital fasciculus (but not cortico-spinal tract) mediated the association between age and EF. Additionally, increased systolic blood pressure and white matter hyperintensity burden within these white matter tracts contribute to worsening white matter health and are important factors underlying age-brain-behavior associations. These findings suggest that aging brings about increases in both BP and WMH burden, which may be involved in the degradation of white matter connectivity and in turn, negatively impact executive functions as we age.
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DOI：
10.1136/bmj.c3666
发表时间：
2010-07-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Debette S;Markus HS
通讯作者：
Markus HS
影响因子：
4.8
作者：
Burzynska, Agnieszka Z.;Nagel, Irene E.;Heekeren, Hauke R.
通讯作者：
Heekeren, Hauke R.
影响因子：
3.5
作者：
Anstey, K;Christensen, H
通讯作者：
Christensen, H
影响因子：
4.2
作者：
Bartzokis, G;Sultzer, D;Cummings, JL
通讯作者：
Cummings, JL
影响因子：
4.2
作者：
Bucur, Barbara;Madden, David J.;Huettel, Scott A.
通讯作者：
Huettel, Scott A.