Simultaneous subcortical and cortical electrophysiological recordings of spectro-temporal processing in humans.
Simultaneous subcortical and cortical electrophysiological recordings of spectro-temporal processing in humans.
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人类光谱-时间处理的同时皮质下和皮质电生理记录。
DOI：
10.3389/fneur.2022.928158
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发表时间：
2022
影响因子：
3.4
通讯作者：
Vickers, Deborah
中科院分区：
文献类型：
--
作者：
Calcus, Axelle;Undurraga, Jaime A.;Vickers, Deborah
关键词：
听觉辨别力的客观评估通常使用听觉变化复合波（ACC）来测量，这是一种由正在进行的长时间听觉刺激内发生的变化引起的皮层产生的电位。在人工耳蜗使用者中，电诱发ACC已被用于通过在刺激呈现期间改变刺激电极来测量电极辨别力。除了这一皮层成分，皮层下的措施提供了进一步的信息，在正常听力的听众和人工耳蜗植入用户的早期听觉处理。特别是，频率跟随反应（FFR）被认为反映了脑干水平的听觉编码。有趣的是，最近的研究表明，有可能同时测量皮层下和皮层的生理活动。本研究的目的是双重的：首先，了解在正常听力成人中同时记录FFR（皮层下）和ACC（皮层）反应的范围。第二，确定最佳记录参数，以优化同时捕获两种反应，并考虑到临床应用。10名听力正常的成年人在听16秒长的纯音序列时记录了电生理反应。这些序列的载波频率在整个序列中是稳定的或周期性地交替，对每个交替产生ACC响应-交替ACC范例。在“交替”序列中，交替速率和载波频率都是参数变化的。我们研究了三个交变速率（1，2.5和6.5 Hz）和七个频率对，覆盖低，中，高频率范围，包括窄和宽的频率间隔。我们的结果表明，最慢（1 Hz）和中等（2.5 Hz）交替率在大多数测试频率范围内均导致显著的FFR和ACC反应。低载波频率导致血流储备分数振幅、P1振幅和N1-P2振幅差在慢交替率下更大。皮层下和皮层反应幅度之间没有显着的关系，符合不同的发电机和处理水平的听觉通路。总的来说，交替ACC范例可用于测量皮层下和皮层响应作为通路中的听觉早期神经编码（FFR）和声音辨别（ACC）的指标，并且这些最好在低频范围（300-1200 Hz）中的缓慢交替速率（1 Hz）下获得。
Objective assessment of auditory discrimination has often been measured using the Auditory Change Complex (ACC), which is a cortically generated potential elicited by a change occurring within an ongoing, long-duration auditory stimulus. In cochlear implant users, the electrically-evoked ACC has been used to measure electrode discrimination by changing the stimulating electrode during stimulus presentation. In addition to this cortical component, subcortical measures provide further information about early auditory processing in both normal hearing listeners and cochlear implant users. In particular, the frequency-following response (FFR) is thought to reflect the auditory encoding at the level of the brainstem. Interestingly, recent research suggests that it is possible to simultaneously measure both subcortical and cortical physiological activity. The aim of this research was twofold: first, to understand the scope for simultaneously recording both the FFR (subcortical) and ACC (cortical) responses in normal hearing adults. Second, to determine the best recording parameters for optimizing the simultaneous capture of both responses with clinical applications in mind. Electrophysiological responses were recorded in 10 normally-hearing adults while they listened to 16-second-long pure tone sequences. The carrier frequency of these sequences was either steady or alternating periodically throughout the sequence, generating an ACC response to each alternation—the alternating ACC paradigm. In the “alternating” sequences, both the alternating rate and the carrier frequency varied parametrically. We investigated three alternating rates (1, 2.5, and 6.5 Hz) and seven frequency pairs covering the low-, mid-, and high-frequency range, including narrow and wide frequency separations. Our results indicate that both the slowest (1 Hz) and medium (2.5 Hz) alternation rates led to significant FFR and ACC responses in most frequency ranges tested. Low carrier frequencies led to larger FFR amplitudes, larger P1 amplitudes, and N1-P2 amplitude difference at slow alternation rates. No significant relationship was found between subcortical and cortical response amplitudes, in line with different generators and processing levels across the auditory pathway. Overall, the alternating ACC paradigm can be used to measure sub-cortical and cortical responses as indicators of auditory early neural encoding (FFR) and sound discrimination (ACC) in the pathway, and these are best obtained at slow alternation rates (1 Hz) in the low-frequency range (300–1200 Hz).
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影响因子：
16.6
作者：
Coffey, Emily B. J.;Nicol, Trent;Kraus, Nina
通讯作者：
Kraus, Nina
影响因子：
1.2
作者：
Alain, Claude;Tremblay, Kelly
通讯作者：
Tremblay, Kelly
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2.8
作者：
Lucchetti, Federico;Nonclercq, Antoine;Deltenre, Paul
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Deltenre, Paul
影响因子：
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作者：
Martin BA;Boothroyd A;Ali D;Leach-Berth T
通讯作者：
Leach-Berth T
影响因子：
2.8
作者：
Gransier R;Guérit F;Carlyon RP;Wouters J
通讯作者：
Wouters J