Cytomegalovirus infections of the nervous system in patients with AIDS.

Cytomegalovirus infections of the nervous system in patients with AIDS.
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艾滋病患者神经系统的巨细胞病毒感染。

DOI:
10.1093/clinids/20.4.747
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发表时间:
1995
期刊:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子:
--
通讯作者:
McCutchan,JA
McCutchan,JA
中科院分区:
--
文献类型:
--
作者:
McCutchan,JA

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巨细胞病毒(CMV)感染引起的视网膜炎是人类免疫缺陷病毒1型(HIV-1)引起的晚期疾病的一种公认的并发症。艾滋病患者中巨细胞病毒感染的其他神经系统表现较少。J.Allen McCutchan博士全面回顾了CMV神经系统疾病的各种临床表现以及诊断方法、现有抗病毒药物的神经药理学、治疗结果以及预防这些晚期免疫抑制后遗症的可能性。随着预防卡氏肺孢子虫肺炎、禽分枝杆菌继发性菌血症、结核病、严重真菌感染和弓形虫脑炎等疾病的能力不断提高,医生现在必须治疗更多患有巨细胞病毒病的HIV-1感染者。这篇艾滋病评论及时更新了我们对这一严重问题的了解现状。
Retinitis due to cytomegalovirus (CMV) infection is a widely recognized complication of advanced disease due to human immunodeficiency virus type 1 (HIV-1). Less appreciated are other neurological manifestations of CMV infection in persons with AIDS. Dr. J. Allen McCutchan has comprehensively reviewed the various clinical presentations of CMV neurological disease as well as the methods of diagnosis, the neuropharmacology of available antiviral agents, the results of therapy, and the potential for prevention of these sequelae of advanced immunosuppression. As the ability to prevent diseases such asPneumocystis cariniipneumonia, bacteremia secondary toMycobacterium avium, tuberculosis, serious fungal infections, and toxoplasma cerebritis is increasing, physicians must now treat more HIV-1-infected persons with CMV disease. This AIDS Commentary provides a timely update of the current state of our knowledge regarding this serious problem.
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