Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device.
Sustained-release ganciclovir therapy for treatment of cytomegalovirus retinitis. Use of an intravitreal device.
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缓释更昔洛韦疗法用于治疗巨细胞病毒性视网膜炎。
DOI：
10.1001/archopht.1992.01080140044023
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发表时间：
1992
影响因子：
--
通讯作者：
Thomas J. Smith
中科院分区：
文献类型：
--
作者：
G. Sanborn;Rajiv Anand;Robert E. Torti;S. Nightingale;Stanley X. Cal;Bradley E. Yates;P. Ashton;Thomas J. Smith
已开发出一种用于玻璃体内持续释放更昔洛韦的手术植入装置。该设备提供更昔洛韦眼内超过约4至5个月。8例获得性免疫缺陷综合征（AIDS）和相关的巨细胞病毒（CMV）视网膜炎患者被招募作为1期研究的一部分。13只患有活动性CMV视网膜炎的眼睛接受了更昔洛韦装置的手术植入。所有眼睛均显示CMV视网膜炎消退;无进展。3眼视力无变化，6眼视力提高，4眼视力下降。手术并发症包括轻度玻璃体出血、散光和脉络膜上腔植入器械。视网膜脱离发生在三只眼睛的视网膜炎解决。这种新的眼内给药系统提供了许多优点相比，静脉治疗或重复玻璃体内注射更昔洛韦治疗艾滋病患者的CMV视网膜炎。
A surgically implantable device for sustained intravitreal release of ganciclovir has been developed. The device delivers ganciclovir intraocularly over approximately 4 to 5 months. Eight patients with acquired immunodeficiency syndrome (AIDS) and associated cytomegalovirus (CMV) retinitis were recruited as part of a phase 1 study. Thirteen eyes with active CMV retinitis underwent surgical implantation of the ganciclovir device. All eyes showed resolution of the CMV retinitis; none showed progression. Visual acuity remained unchanged in three eyes, improved in six eyes, and decreased in four eyes. Surgical complications included mild vitreous hemorrhage, astigmatism, and suprachoroidal placement of the device. Retinal detachment occurred in three eyes as the retinitis resolved. This new intraocular drug delivery system offers many advantages compared with intravenous therapy or repeated intravitreal ganciclovir injections for the management of CMV retinitis in patients with AIDS.
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影响因子：
13.7
作者：
Pepose,JS;Holland,GN;Nestor,MS;Cochran,AJ;Foos,RY
通讯作者：
Foos,RY
获得性免疫缺陷综合征中巨细胞病毒视网膜炎的纵向研究。
影响因子：
13.7
作者：
Gross,JG;Bozzette,SA;Mathews,WC;Spector,SA;Abramson,IS;McCutchan,JA;Mendez,T;Munguia,D;Freeman,WR
通讯作者：
Freeman,WR
用抗病毒药物更昔洛韦治疗后巨细胞病毒视网膜病的病理特征。
影响因子：
13.7
作者：
Pepose,JS;Newman,C;Bach,MC;Quinn,TC;Ambinder,RF;Holland,GN;Hodstrom,PS;Frey,HM;Foos,RY
通讯作者：
Foos,RY
影响因子：
13.7
作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
通讯作者：
G. Holland;G. Holland;J. Pepose;T. H. Pettit;T. H. Pettit;M. Gottlieb;R. Yee;R. Yee;R. Foos;R. Foos
影响因子：
--
作者：
JABS, DA;ENGER, C;BARTLETT, JG
通讯作者：
BARTLETT, JG