Fat-like cadherins in cell migration-leading from both the front and the back.
Fat-like cadherins in cell migration-leading from both the front and the back.
复制标题
细胞迁移中的脂肪样钙粘蛋白——从正面和背面引导。
DOI：
10.1016/j.ceb.2017.04.003
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发表时间：
2017
影响因子：
7.5
通讯作者：
Horne-Badovinac,Sally
中科院分区：
文献类型：
--
作者：
Horne-Badovinac,Sally
重点脂肪样钙粘蛋白作为多种细胞类型的促迁移信号蛋白。哺乳动物中的脂肪样钙粘蛋白似乎促进从细胞前部的迁移。果蝇中的脂肪样钙粘蛋白促进从细胞后部的迁移。未来的工作可能会表明两种机制在两种模型中都起作用。当细胞在体内迁移时，它们的运动性不断受到与其他细胞相互作用的影响。脂肪样钙粘蛋白是促进多种细胞类型迁移的细胞-细胞信号蛋白。然而，最近的研究表明，脂肪样钙粘蛋白在哺乳动物和果蝇中对运动的影响不同，钙粘蛋白作用于哺乳动物细胞的前缘和果蝇细胞的后缘。与生物体之间的差异相反，脂肪样钙粘蛋白更可能是高度通用的蛋白质，可以以多种方式与迁移机制相互作用。在这里，我回顾什么是已知的脂肪样钙粘蛋白促进迁移，然后探讨在哺乳动物和果蝇模型之间可能会发现保守的功能。
HighlightsFat-like cadherins act as pro-migratory signaling proteins for multiple cell types.Fat-like cadherins in mammals appear to promote migration from the front of the cell.Fat-like cadherins in Drosophila promote migration from the back of the cell.Future work is likely to show that both mechanisms are operating in both models.When cells migrate through the body, their motility is continually influenced by interactions with other cells. The Fat-like cadherins are cell–cell signaling proteins that promote migration in multiple cell types. Recent studies suggest, however, that Fat-like cadherins influence motility differently in mammals versus Drosophila, with the cadherin acting at the leading edge of mammalian cells and the trailing edge of Drosophila cells. As opposed to this being a difference between organisms, it is more likely that the Fat-like cadherins are highly versatile proteins that can interact with the migration machinery in multiple ways. Here, I review what is known about how Fat-like cadherins promote migration, and then explore where conserved features may be found between the mammalian and Drosophila models.
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