Tyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptors.
Tyrosine kinase signalling in breast cancer: fibroblast growth factors and their receptors.
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DOI：
10.1186/bcr53
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Fantl V
中科院分区：
文献类型：
--
作者：
Dickson C;Spencer-Dene B;Dillon C;Fantl V
成纤维细胞生长因子[FGF（鼠）、FGF（人）]构成通过一类细胞表面酪氨酸激酶受体发出信号的配体大家族。成纤维细胞生长因子信号已在体外与细胞分化以及有丝分裂和运动反应。在体内，FGFs对动物发育至关重要，并且一些具有有效的血管生成特性。几种Fgf已被鉴定为鼠乳腺癌中的癌基因，其中它们的失调与小鼠乳腺肿瘤病毒（MMTV）的前病毒插入相关。因此，在一些乳腺肿瘤的MMTV感染的小鼠品系，整合到乳腺上皮细胞的体细胞DNA的病毒基因组DNA被发现已导致该家族的生长因子的成员的不适当的表达。尽管对人类乳腺癌的检查显示，FGF或其受体在某些肿瘤中的表达发生了变化，但它们在乳腺疾病病因中的作用尚不清楚，仍存在争议。
The fibroblast growth factors [Fgfs (murine), FGFs (human)] constitute a large family of ligands that signal through a class of cell-surface tyrosine kinase receptors. Fgf signalling has been associated in vitro with cellular differentiation as well as mitogenic and motogenic responses. In vivo, Fgfs are critical for animal development, and some have potent angiogenic properties. Several Fgfs have been identified as oncogenes in murine mammary cancer, where their deregulation is associated with proviral insertions of the mouse mammary tumour virus (MMTV). Thus, in some mammary tumours of MMTV-infected mouse strains, integration of viral genomic DNA into the somatic DNA of mammary epithelial cells was found to have caused the inappropriate expression of members of this family of growth factors. Although examination of human breast cancers has shown an altered expression of FGFs or of their receptors in some tumours, their role in the causation of breast disease is unclear and remains controversial.
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影响因子：
8.8
作者：
Linder, C;Byström, P;Linder, S
通讯作者：
Linder, S
影响因子：
64.5
作者：
DEVORE, DL;HORVITZ, HR;STERN, MJ
通讯作者：
STERN, MJ
影响因子：
8.8
作者：
Coope RC;Browne PJ;Yiangou C;Bansal GS;Walters J;Groome N;Shousha S;Johnston CL;Coombes RC;Gomm JJ
通讯作者：
Gomm JJ
影响因子：
5.4
作者：
MACARTHUR, CA;SHANKAR, DB;SHACKLEFORD, GM
通讯作者：
SHACKLEFORD, GM
影响因子：
4
作者：
DeMoerlooze, L;Dickson, C
通讯作者：
Dickson, C