Impact of overactive bladder on quality of life and resource use: results from Korean Burden of Incontinence Study (KOBIS).
Impact of overactive bladder on quality of life and resource use: results from Korean Burden of Incontinence Study (KOBIS).
复制标题
膀胱过度活跃对生活质量和资源使用的影响：韩国失禁研究负担（Kobis）的结果。
DOI：
10.1186/s12955-015-0274-9
复制
发表时间：
2015-06-26
影响因子：
3.6
通讯作者：
Kim JC
中科院分区：
文献类型：
--
作者：
Lee KS;Choo MS;Seo JT;Oh SJ;Kim HG;Ng K;Lee KJ;Tan JT;Kim JC
评估从韩国6家医院招募的患者膀胱过动症（OAB）对生活质量（QOL）、资源利用和生产力损失的影响。这项横断面调查在2013年7月至12月期间招募了625名OAB患者。根据过去三天尿失禁（UI）发作的平均次数（0、1、2-3和≥4 UI/天）将患者分为四组。使用尿失禁特异性生活质量量表（I-QOL）、膀胱过度活动问卷（OAB-q）和通用健康相关实用工具（EQ-5D）来测量生活质量。还收集了有关医院和诊所就诊频率以及自制垫使用情况的信息。使用工作效率和活动障碍（WPAI）问卷评估工作效率。采用方差分析评估组间差异。采用多变量回归分析来检验OAB症状对生活质量的独立影响。尿失禁严重程度与生活质量呈显著的线性关系，各尿失禁严重程度类别间差异有临床意义。与干燥类相比，最严重类（≥4 UI/天）患者的I-QOL评分显著降低（69.8 vs 42.6, p < 0.0001）， OAB-q的症状困扰更大（30.4 vs 64.6, p < 0.0001）， EQ-5D效用更差（0.848 vs 0.742, p < 0.001）。多变量分析显示尿失禁的严重程度、频率、急迫性和夜尿症与较差的生活质量独立相关。尿失禁严重程度也与尿失禁垫的成本显著相关（p < 0.0001），对工作和日常活动的干扰更大（p = 0.001），然而，在医院和诊所就诊方面没有观察到显著差异。即使考虑到与OAB相关的其他症状的影响，尿失禁的严重程度也是韩国OAB患者疾病负担的关键因素。本文的在线版本（doi:10.1186/s12955-015-0274-9）包含补充材料，可供授权用户使用。
To evaluate the impact of overactive bladder (OAB) on quality of life (QOL), resource use and productivity loss in patients recruited from six hospitals in Korea. This cross-sectional survey recruited 625 OAB patients between July to December 2013. Patients were categorised into four groups based on the average number of urinary incontinence (UI) episodes over the past three days (0, 1, 2–3 and ≥4 UI/day). QOL was measured using the Incontinence-Specific Quality of Life Instrument (I-QOL), the Overactive Bladder Questionnaire (OAB-q), and a generic health-related utility instrument (EQ-5D). Information on hospital and clinic visit frequency, and continence pads use were also collected. Work productivity was assessed using the Work Productivity and Activity Impairment (WPAI) questionnaire. Between group differences were assessed using ANOVA. Multivariable regression analyses were performed to examine the independent effects of OAB symptoms on QOL. Severity of UI showed a significant linear relationship with QOL, with clinically meaningful differences between each UI severity category. Compared to the dry category, patients in the most severe category (≥4 UI/day) had significantly lower I-QOL scores (69.8 vs 42.6; p < 0.0001), greater symptom bother on the OAB-q (30.4 vs 64.6; p < 0.0001), and poorer EQ-5D utility (0.848 vs 0.742; p < 0.001). Multivariable analyses showed that UI severity, frequency, urgency, and nocturia are independently associated with poorer QOL. Incontinence severity is also significantly associated with cost of incontinence pads (p < 0.0001), and a greater interference with work and regular activities (p = 0.001), however, no significant difference in hospital and clinic visits were observed. Severity of UI is a key contributor to the disease burden of OAB in Korean patients, even after taking into account the impact of other symptoms associated with OAB. The online version of this article (doi:10.1186/s12955-015-0274-9) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
2.3
作者：
Oh SJ;Son H;Kim SW;Lee KS;Choo MS;Kim SO;Lee MS
通讯作者：
Lee MS
影响因子：
2.9
作者：
Kurita N;Yamazaki S;Fukumori N;Otoshi K;Otani K;Sekiguchi M;Onishi Y;Takegami M;Ono R;Horie S;Konno S;Kikuchi S;Fukuhara S
通讯作者：
Fukuhara S
影响因子：
2
作者：
Dyer, Keisha Y.;Xu, Yan;Lukacz, Emily
通讯作者：
Lukacz, Emily
影响因子：
4.4
作者：
Drummond, M
通讯作者：
Drummond, M
影响因子：
5.4
作者：
Marra, CA;Woolcott, JC;Anis, AH
通讯作者：
Anis, AH