Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics.
Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics.
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DOI：
10.1111/j.1476-5381.2009.00057.x
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发表时间：
2009-05
影响因子：
7.3
通讯作者：
Divita G
中科院分区：
文献类型：
--
作者：
Heitz F;Morris MC;Divita G
最近发现的新的有效治疗分子由于递送不良和生物利用度低而无法到达临床，使递送成为治疗开发的关键。已经设计了几种技术来改善治疗分子的细胞摄取，包括细胞穿透肽（CPP）。CPP最初是基于几种蛋白质进入细胞的能力而发现的。到目前为止，已经描述了许多CPP，它们可以分为两大类，第一类需要与药物进行化学连接以进行细胞内化，第二类涉及与药物形成稳定的非共价复合物。如今，CPP构成了用于货物的非侵入性细胞输入的非常有前途的工具，并且已经成功地应用于从小化学分子、核酸、蛋白质、肽、脂质体和颗粒变化的治疗性分子的体外和体内递送。本文将重点介绍CPPs的结构/功能和细胞摄取机制在药物输送的一般情况下。我们还将重点介绍肽载体在治疗分子递送中的应用，并提供其临床评价的更新。本文是载体设计和药物递送主题部分的一部分。有关本节中所有文章的列表，请参阅本文的结尾，或访问：http://www3.interscience.wiley.com/journal/121548564/issueyear?年份=2009年
The recent discovery of new potent therapeutic molecules that do not reach the clinic due to poor delivery and low bioavailability have made of delivery a key stone in therapeutic development. Several technologies have been designed to improve cellular uptake of therapeutic molecules, including cell-penetrating peptides (CPPs). CPPs were first discovered based on the potency of several proteins to enter cells. Numerous CPPs have been described so far, which can be grouped into two major classes, the first requiring chemical linkage with the drug for cellular internalization and the second involving formation of stable, non-covalent complexes with drugs. Nowadays, CPPs constitute very promising tools for non-invasive cellular import of cargo and have been successfully applied for in vitro and in vivo delivery of therapeutic molecules varying from small chemical molecule, nucleic acids, proteins, peptides, liposomes and particles. This review will focus on the structure/function and cellular uptake mechanism of CPPs in the general context of drug delivery. We will also highlight the application of peptide carriers for the delivery of therapeutic molecules and provide an update of their clinical evaluation. This article is part of a themed section on Vector Design and Drug Delivery. For a list of all articles in this section see the end of this paper, or visit: http://www3.interscience.wiley.com/journal/121548564/issueyear?year=2009
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影响因子：
5.3
作者：
Davidson, TJ;Harel, S;Troy, CM
通讯作者：
Troy, CM
DOI：
10.1038/nrd2310
发表时间：
2007-06
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
de Fougerolles A;Vornlocher HP;Maraganore J;Lieberman J
通讯作者：
Lieberman J
影响因子：
3.4
作者：
Deshayes, S;Gerbal-Chaloin, S;Heitz, F
通讯作者：
Heitz, F
影响因子：
64.5
作者：
Elliott, G;OHare, P
通讯作者：
OHare, P
影响因子：
5.4
作者：
Burrer, Renaud;Neuman, Benjamin W.;Buchmeier, Michael J.
通讯作者：
Buchmeier, Michael J.