Advances in the study of axon-associated vesicles.
Advances in the study of axon-associated vesicles.
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DOI：
10.3389/fnmol.2022.1045778
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发表时间：
2022
影响因子：
4.8
通讯作者：
Wu, Xiao-Mei
中科院分区：
文献类型：
--
作者：
Liu, Yanling;Shuai, Ke;Sun, Yiyan;Zhu, Li;Wu, Xiao-Mei
中枢神经系统是人体中最重要也是最难研究的系统，以其复杂的功能、组成和机制而闻名。神经元是实现神经功能的基本细胞单元。在神经元中，囊泡是细胞内物质运输的关键途径之一，连接着细胞内外的信息交换。轴突是神经元的重要组成部分，因为电信号和分子信号必须通过轴突传导。在这里，我们描述和探索轴突内细胞小泡的形成、运输和分类，以及相关的疾病和实际意义。此外，随着认识的深入和新方法的发展，越来越多的证据表明，除了突触之间的信号传递外，轴突与细胞外环境之间的物质交换和囊泡传递也参与了生理过程，从而参与了神经病理学。最近的研究也关注轴突小泡及其对轴突本身的生理作用和病理影响。因此，本文主要围绕这两个关键节点来解释细胞内小泡和细胞外小泡迁移到轴突和神经元上的作用，为以后的研究提供创新策略。
The central nervous system is the most important and difficult to study system in the human body and is known for its complex functions, components, and mechanisms. Neurons are the basic cellular units realizing neural functions. In neurons, vesicles are one of the critical pathways for intracellular material transport, linking information exchanges inside and outside cells. The axon is a vital part of neuron since electrical and molecular signals must be conducted through axons. Here, we describe and explore the formation, trafficking, and sorting of cellular vesicles within axons, as well as related-diseases and practical implications. Furthermore, with deepening of understanding and the development of new approaches, accumulating evidence proves that besides signal transmission between synapses, the material exchange and vesicular transmission between axons and extracellular environment are involved in physiological processes, and consequently to neural pathology. Recent studies have also paid attention to axonal vesicles and their physiological roles and pathological effects on axons themselves. Therefore, this review mainly focuses on these two key nodes to explain the role of intracellular vesicles and extracellular vesicles migrated from cells on axons and neurons, providing innovative strategy for future researches.
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影响因子：
16.6
作者：
Angerani S;Lindberg E;Klena N;Bleck CKE;Aumeier C;Winssinger N
通讯作者：
Winssinger N
影响因子：
10.5
作者：
Cross JA;Woolfson DN;Dodding MP
通讯作者：
Dodding MP
DOI：
10.1093/brain/awab113
发表时间：
2021-07-28
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Akin EJ;Alsaloum M;Higerd GP;Liu S;Zhao P;Dib-Hajj FB;Waxman SG;Dib-Hajj SD
通讯作者：
Dib-Hajj SD
影响因子：
1.7
作者：
Bearzatto, B;Lesage, F;Laduron, PM
通讯作者：
Laduron, PM
征素介导的线粒体沿神经元过程的顺行转运。
影响因子：
7.8
作者：
Cai, Qian;Gerwin, Claudia;Sheng, Zu-Hang
通讯作者：
Sheng, Zu-Hang