Adolescent social isolation increases cocaine seeking in male and female mice.
Adolescent social isolation increases cocaine seeking in male and female mice.
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DOI：
10.1016/j.bbr.2018.10.007
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发表时间：
2019-02-01
影响因子：
2.7
通讯作者：
Briand LA
中科院分区：
文献类型：
--
作者：
Fosnocht AQ;Lucerne KE;Ellis AS;Olimpo NA;Briand LA
儿童和青少年的逆境与各种精神疾病有关，包括药物滥用的风险增加。尽管如此，青春期慢性压力改变奖励信号的潜在机制仍然在很大程度上未被探索。了解青少年压力如何增加成瘾样表型可以为吸毒前后有针对性的干预措施的制定提供信息。目前的研究检查了从青春期开始的长期隔离压力如何影响雄性和雌性小鼠对可卡因反应的行为和神经元基础。青少年发病的社会隔离并没有改变小鼠学习食物的操作性反应的能力，也没有影响食物自我管理或食物的动机的渐进比例时间表。然而，男性和女性的社会隔离小鼠表现出增加可卡因和可卡因寻求在线索诱导恢复会话的动机。此外，我们证明，可卡因引起的神经元激活，c-Fos表达的评估，神经核内的丘脑核的核心和外壳，腹侧苍白球，终纹背床核，外侧隔和基底外侧杏仁核的发作性社会隔离增加。综上所述，目前的研究表明，青少年时期的社会隔离压力增加了成年期对可卡因的行为反应，并改变了与奖励相关的脑回路的反应。
Childhood and adolescent adversity are associated with a wide range of psychiatric disorders, including an increased risk for substance abuse. Despite this, the mechanisms underlying the ability of chronic stress during adolescence to alter reward signaling remains largely unexplored. Understanding how adolescent stress increases addiction-like phenotypes could inform the development of targeted interventions both before and after drug use. The current study examined how prolonged isolation stress, beginning during adolescence, affected behavioral and neuronal underpinnings to the response to cocaine in male and female mice. Adolescent-onset social isolation did not alter the ability of mice to learn an operant response for food, nor influence food self-administration or motivation for food on a progressive ratio schedule. However, male and female social isolation mice exhibited an increase in motivation for cocaine and cocaine seeking during a cue-induced reinstatement session. Additionally, we demonstrated that adolescent-onset social isolation increased cocaine-induced neuronal activation, as assessed by c-Fos expression, within the nucleus accumbens core and shell, ventral pallidum, dorsal bed nucleus of the stria terminalis, lateral septum and basolateral amygdala. Taken together, the present studies demonstrate that social isolation stress during adolescence augments the behavioral responses to cocaine during adulthood and alters the responsiveness of reward-related brain circuitry.
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影响因子：
16.2
作者：
Creed M;Ntamati NR;Chandra R;Lobo MK;Lüscher C
通讯作者：
Lüscher C
DOI：
10.1523/jneurosci.2827-10.2010
发表时间：
2010-12-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Briand LA;Vassoler FM;Pierce RC;Valentino RJ;Blendy JA
通讯作者：
Blendy JA
影响因子：
3.4
作者：
Burke AR;Miczek KA
通讯作者：
Miczek KA
影响因子：
4.8
作者：
Brents, Lisa K.;Tripathi, Shanti Prakash;Kilts, Clinton D.
通讯作者：
Kilts, Clinton D.
影响因子：
7.6
作者：
Arguello, Amy A.;Richardson, Ben D.;Fuchs, Rita A.
通讯作者：
Fuchs, Rita A.