Virology, epidemiology, immunology and vaccine development of SARS-CoV-2, update after nine months of pandemic.

Virology, epidemiology, immunology and vaccine development of SARS-CoV-2, update after nine months of pandemic.
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DOI:
10.1016/j.biologicals.2020.11.003
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发表时间:
2021-01
期刊:
Biologicals : journal of the International Association of Biological Standardization
影响因子:
--
通讯作者:
Neels P
Neels P
中科院分区:
其他
文献类型:
--
作者:
Baay M;Lina B;Fontanet A;Marchant A;Saville M;Sabot P;Vandeputte J;Neels P

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在新冠肺炎被宣布为国际关注的突发公共卫生事件没几个月后,组织了这次国际生物标准化联盟网络研讨会,以提供关于SARS-CoV-2的病毒学、流行病学和免疫学以及疫苗开发的最新情况。它汇集了广泛的国际利益攸关方,包括学术界、监管者、资助者和工业界,以及来自低收入和中等收入国家的相当多的代表团。重组可能导致了一种获得人际传播能力的病毒。最初,第二波SARS-CoV-2感染被错误地解读为更良性的。中和抗体可能有助于控制SARS-CoV-2疾病。粘膜免疫反应(鼻粘液或唾液中的IgA)可能是一种有用的保护相关性。Covax的目标是到2021年底向世界所有国家提供20亿剂疫苗。
This International Alliance for Biological Standardization COVID-19 webinar was organized to provide an update on the virology, epidemiology and immunology of, and the vaccine development for SARS-CoV-2, none months after COVID-19 was declared a public health emergency of international concern. It brought together a broad range of international stakeholders, including academia, regulators, funders and industry, with a considerable delegation from low- and middle-income countries. Recombination probably led to a virus that acquired human-to-human transmissibility. Initially, SARS-CoV-2 infection in the second wave was mistakenly interpreted as more benign. Neutralizing antibodies likely contribute to control of SARS-CoV-2 disease. A mucosal immune response (IgA in nasal mucus or saliva) may be a useful correlate of protection. COVAX aims to deliver 2 billion doses of vaccine by the end of 2021, to all the countries around the world.
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