Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5.
Distinct pathways for signaling maturation in macrophages and dendritic cells after infection with paramyxovirus simian virus 5.
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副粘病毒猴病毒 5 感染后巨噬细胞和树突状细胞中信号成熟的不同途径。
DOI：
10.1089/vim.2006.0070
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发表时间：
2007
期刊：
影响因子：
2.2
通讯作者：
Alexander-Miller,MarthaA
中科院分区：
文献类型：
--
作者：
Pejawar-Gaddy,Sharmila;Gitiban-Vaghefi,Negin;Parks,GriffithD;Alexander-Miller,MarthaA
Professional antigen-presenting cells are critical components of both the innate and adaptive immune responses. Although dendritic cells (DCs) are generally thought to be the primary activators of naive T cells, macrophages have also been shown to fulfill this role. As with DCs, the capacity to induce optimal activation of T cells requires that macrophages undergo a process that results in the increased expression of costimulatory molecules, such as CD40, CD80, and CD86, and the production of cytokines. In this study we analyzed the effect of infection of macrophages generated from BALB/c mice with the paramyxovirus simian virus 5 (SV5). Here we have shown that bone marrow-derived macrophages (BMMs) are not productively infected at any multiplicity of infection tested. Analysis of activation markers revealed that SV5-infected BMMs robustly upregulated CD40 and modestly upregulated CD86, but did not upregulate the expression of CD80. Further, SV5-infected BMMs secreted low levels of interferon-β and interleukin (IL)-12p40, but high levels of tumor necrosis factor-α and IL-6. Intriguingly, upregulation of these molecules on BMMs, unlike our previous results using bone marrow-derived dendritic cells, was not dependent on live virus. These findings provide evidence that different professional antigen-presenting cells can detect and respond to virus via distinct mechanisms.
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