Human Hepatitis B Virus Negatively Impacts the Protective Immune Crosstalk Between Natural Killer and Dendritic Cells.
Human Hepatitis B Virus Negatively Impacts the Protective Immune Crosstalk Between Natural Killer and Dendritic Cells.
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DOI：
10.1002/hep.31725
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Ferlazzo G
中科院分区：
文献类型：
--
作者：
De Pasquale C;Campana S;Barberi C;Sidoti Migliore G;Oliveri D;Lanza M;Musolino C;Raimondo G;Ferrone S;Pollicino T;Ferlazzo G
NK cells play a crucial role in the clearance of human viruses but their activity is significantly impaired in chronic hepatitis B infected patients (CHB). Cooperation with dendritic cells (DCs) is pivotal for obtaining optimal NK cell antiviral function, thus we investigated whether HBV might impact the ability of DCs to sustain NK cell functions. Human DCs were poor stimulators of IFN-γ production by NK cells when exposed to HBV, while maintained capability to trigger NK cell cytotoxicity. HBV prevented DC maturation but did not affect their expression of HLA class I, thus allowing DCs to evade NK cell lysis. Tolerogenic features of DCs exposed to HBV were further supported by their increased expression of IL-10 and immunosuppressive enzyme indoleamine-2, 3-dioxygenase that contributed to the impairment of DC-mediated NK cell IFN-γ production and proliferation respectively. HBV could also inhibit the expression of inducible immunoproteasome (iP) subunits on DCs. In fact, NK cells could induce iP subunit expression on DCs but they failed in the presence of HBV. Remarkably, circulating BDCA1+DCs isolated from CHB patients were functionally compromised, hence altering, in turn, NK cell responses. The abnormal NK/DC interplay caused by HBV may significantly impair the efficacy of antiviral immune response in CHB patients.
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DOI：
10.1084/jem.20010938
发表时间：
2002-02-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gerosa F;Baldani-Guerra B;Nisii C;Marchesini V;Carra G;Trinchieri G
通讯作者：
Trinchieri G
影响因子：
3.6
作者：
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影响因子：
30.5
作者：
Andrews, DM;Scalzo, AA;Degli-Esposti, MA
通讯作者：
Degli-Esposti, MA
免疫蛋白酶体塑造抗病毒CD8（+）T细胞在T细胞库水平和病毒抗原的表现下的免疫主导层次结构。
影响因子：
15.3
作者：
Chen, W;Norbury, C C;Cho, Y;Yewdell, J W;Bennink, J R
通讯作者：
Bennink, J R
DOI：
10.1002/hep.30246
发表时间：
2019-03
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Nguyen MH;Lim JK;Burak Ozbay A;Fraysse J;Liou I;Meyer N;Dusheiko G;Gordon SC
通讯作者：
Gordon SC