The inflammatory potential of the diet in childhood is associated with cardiometabolic risk in adolescence/young adulthood in the ALSPAC birth cohort.
The inflammatory potential of the diet in childhood is associated with cardiometabolic risk in adolescence/young adulthood in the ALSPAC birth cohort.
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DOI：
10.1007/s00394-022-02860-9
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发表时间：
2022-10
影响因子：
5
通讯作者：
Taylor, Caroline M.
中科院分区：
文献类型：
--
作者：
Buckland, Genevieve;Northstone, Kate;Emmett, Pauline M.;Taylor, Caroline M.
关键词：
本研究在雅芳父母和儿童纵向研究（ALSPAC）中检查了青少年/成年早期的儿童饮食炎症评分（cDIS）和心脏代谢风险（CMR）评分之间的相关性。使用饮食日记数据计算第7、10和13年的cDIS。使用17岁（N = 1937）和24岁（N = 1957）时的人体测量和生化数据计算每个年龄的CMR评分[来自三酰甘油、HDL-胆固醇、LDL-胆固醇、平均动脉血压（MAP）、胰岛素抵抗的稳态模型评估（HOMA-IR）和脂肪质量指数（FMI）的平均性别特异性z评分]。多变量线性回归模型检查了7、10和13岁时cDIS与连续CMR z评分和17和24岁时个体CMR标志物之间的相关性。在完全校正的模型中，第7年时较高的cDIS（更多促炎饮食）与第17年（β 0.19;第三个与第一个cDIS三分位数的95% CI 0.03-0.35）和第24年（β 0.28;第三个与第一个cDIS三分位数的95% CI 0.11，0.44）时CMR z评分的增加相关。第10年时cDIS较高与第17年时CMR z评分增加之间存在弱相关性（β 0.16;第三个与第一个cDIS三分位数的95% CI − 0.003，0.32）。没有其他明显的关联。FMI、MAP和HOMA-IR是导致这些关联的主要CMR因素。儿童时期的促炎性饮食与青春期后期/成年早期的心脏代谢特征相关。儿童饮食中富含具有抗炎特性的营养素可以帮助减少CMR因子的发展。在线版本包含补充材料，可通过10.1007/s 00394 -022-02860-9获得。
This study examined the association between a Dietary Inflammatory Score adapted for children (cDIS) and Cardiometabolic Risk (CMR) score in adolescence/early adulthood in the Avon Longitudinal Study of Parents and Children (ALSPAC). The cDIS was calculated at 7, 10 and 13 years using diet diary data. Anthropometric and biochemical data at 17 (N = 1937) and 24 (N = 1957) years were used to calculate CMR scores at each age [mean sex-specific z-scores from triacylglycerol, HDL-cholesterol, LDL-cholesterol, mean arterial blood pressure (MAP), homeostatic model assessment of insulin resistance (HOMA-IR) and fat-mass index (FMI)]. Multivariable linear regression models examined associations between cDIS at 7, 10 and 13 years and a continuous CMR z-score and individual CMR markers at 17 and 24 years. In fully adjusted models, a higher cDIS (more pro-inflammatory diet) at 7 years was associated with an increase in CMR z-score at 17 years (β 0.19; 95% CI 0.03–0.35 for third versus first cDIS tertile) and at 24 years (β 0.28; 95% CI 0.11,0.44 for third versus first cDIS tertile). There was a weak association between a higher cDIS at 10 years and an increase in CMR z-score at 17 years (β 0.16; 95% CI − 0.003, 0.32 for third versus first cDIS tertile). No other clear associations were evident. FMI, MAP and HOMA-IR were the main CMR factors contributing to these associations. A more pro-inflammatory diet during childhood was associated with a worse cardiometabolic profile in late adolescence/early adulthood. A childhood diet abundant in nutrients with anti-inflammatory properties could help reduce development of CMR factors. The online version contains supplementary material available at 10.1007/s00394-022-02860-9.
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影响因子：
7.1
作者：
Agudo, Antonio;Cayssials, Valerie;Jakszyn, Paula
通讯作者：
Jakszyn, Paula
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
8
作者：
Crawley, Esther;Hughes, Rachael;Sterne, Jonathan A. C.
通讯作者：
Sterne, Jonathan A. C.
影响因子：
2
作者：
Correa-Rodriguez, Maria;Gonzalez-Jimenez, Emilio;Schmidt-RioValle, Jacqueline
通讯作者：
Schmidt-RioValle, Jacqueline
DOI：
10.2174/1871530314666140922153350
发表时间：
2014
期刊：
Endocrine, metabolic & immune disorders drug targets
影响因子：
--
作者：
Casas R;Sacanella E;Estruch R
通讯作者：
Estruch R