Regulation of Cortisol in Patients Undergoing Total Joint Arthoplasty.
Regulation of Cortisol in Patients Undergoing Total Joint Arthoplasty.
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DOI：
10.1177/1076029621987614
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Hopkinson W
中科院分区：
文献类型：
--
作者：
Khanna R;Slovacek H;Liles J;Haddad S;Poredos P;Bontekoe E;Jezovnik M;Hoppensteadt D;Fareed J;Hopkinson W
骨关节炎是一种关节软骨和骨随时间逐渐退化的疾病。全关节置换术是一种明确的治疗方法。皮质醇是一种与疼痛和炎症有关的激素。本研究旨在探讨全关节置换术患者的皮质醇水平。71例全关节置换术（TJA）患者在基线（术前）、术后24小时和术后5天采集血浆样本。使用市售的ELISA试剂盒测量每个样品中的皮质醇水平。所有结果以组均值±SD编制。基线时血浆皮质醇水平为218.5±12 ng/mL。术后24小时样本显示皮质醇水平明显升高240.7±15 ng/mL。术后第5天采血呈下降趋势（74±12 ng/mL）。术后5天，皮质醇水平明显低于基线或术后24小时。这些结果表明，在手术前，患者的情绪压力会导致血清皮质醇水平升高。由于手术引起的炎症，高水平的皮质醇在手术后24小时持续存在。这些数据还表明，在术后5天，手术引起的炎症反应和情绪压力消退，导致皮质醇水平接近正常化。皮质醇是一种激素，在人体对手术的反应中起着重要作用。皮质醇与手术时间点之间的相关性具有预测和改善恢复措施的潜力。
Osteoarthritis is a condition in which joint cartilage and bone degenerate progressively over time. Total joint arthroplasty is a definitive treatment. Cortisol is a hormone that is associated with pain and inflammation. This study aims to investigate the cortisol levels in patients undergoing total joint arthroplasty. Plasma samples were collected from 71 total joint arthroplasty (TJA) patients at baseline (pre-surgery), 24 hours post-operation, and 5 days post-operation. Cortisol levels were measured in each sample using a commercially available ELISA kit. All results were compiled as group means ± SD. The plasma cortisol level at baseline were 218.5 ± 12 ng/mL. The 24-hour post-surgical samples showed a marked increase in cortisol levels 240.7 ± 15 ng/mL. The blood samples drawn at the 5th day after surgery showed a downward trend (74 ± 12 ng/mL). At 5 days post-operation, cortisol levels were significantly lower than at baseline or 24 hours post-operation. These results point to the fact that prior to surgery, the patient’s emotional stress contributes to increased serum cortisol levels. The higher level of cortisol persists at 24 hours post-operation due to inflammation from the procedure. This data also suggests that at 5 days post-operation, the inflammatory response from the surgery and emotional stress subside, resulting in a near normalization of the cortisol levels. Cortisol is a hormone that plays a major role in the body’s response to surgery. The relevance between cortisol and different points in the surgical timeline has the potential to prognosticate and improve recovery measures.
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影响因子：
3.8
作者：
Lee DY;Kim E;Choi MH
通讯作者：
Choi MH
影响因子：
2
作者：
Petrowskit, Katja;Ritzka, Desiree;Leimert, Mario
通讯作者：
Leimert, Mario
影响因子：
4.1
作者：
de Heide, Loek J. M.;de Boer, Hannah H. R.;de Boer, Hans
通讯作者：
de Boer, Hans
DOI：
10.1016/j.berh.2014.01.004
发表时间：
2014-02-01
影响因子：
5.2
作者：
Johnson, Victoria L.;Hunter, David J.
通讯作者：
Hunter, David J.
DOI：
10.1186/cc12548
发表时间：
2013-03-01
期刊：
Critical care (London, England)
影响因子：
--
作者：
Kazmierski J;Banys A;Latek J;Bourke J;Jaszewski R
通讯作者：
Jaszewski R