Intracellular dynamics of hippocampal place cells during virtual navigation.
Intracellular dynamics of hippocampal place cells during virtual navigation.
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作者：
Hippocampal place cells encode spatial information in rate and temporal codes. To examine the mechanisms underlying hippocampal coding, we measured the intracellular dynamics of place cells by combining in vivo whole cell recordings with a virtual reality system. Head-restrained mice, running on a spherical treadmill, interacted with a computer-generated visual environment to perform spatial behaviors. Robust place cell activity was present during movement along a virtual linear track. From whole cell recordings, we identified three subthreshold signatures of place fields: (1) an asymmetric ramp-like depolarization of the baseline membrane potential; (2) an increase in the amplitude of intracellular theta oscillations; and, (3) a phase precession of the intracellular theta oscillation relative to the extracellularly-recorded theta rhythm. These intracellular dynamics underlie the primary features of place cell rate and temporal codes. The virtual reality system developed here will enable new experimental approaches to study the neural circuits underlying navigation.
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影响因子：
1.9
作者：
Chahl, JS;Srinivasan, MV
通讯作者：
Srinivasan, MV
影响因子：
16.2
作者：
Kentros, CG;Agnihotri, NT;Kandel, ER
通讯作者：
Kandel, ER
影响因子：
64.8
作者：
Huber, Daniel;Petreanu, Leopoldo;Svoboda, Karel
通讯作者：
Svoboda, Karel
影响因子：
3.5
作者：
通讯作者：
--
DOI：
10.1523/jneurosci.1704-07.2007
发表时间：
2007-07-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cacucci F;Wills TJ;Lever C;Giese KP;O'Keefe J
通讯作者：
O'Keefe J