The human leukocyte antigen HLA DRB3*020/DQA1*0501 haplotype is associated with Graves' disease in African Americans.
The human leukocyte antigen HLA DRB3*020/DQA1*0501 haplotype is associated with Graves' disease in African Americans.
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人类白细胞抗原 HLA DRB3*020/DQA1*0501 单倍型与非裔美国人的格雷夫斯病相关。
DOI：
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发表时间：
2000
影响因子：
5.8
通讯作者：
N. Maclaren
中科院分区：
文献类型：
--
作者：
Q. Y. Chen;D. Nadell;X. Y. Zhang;A. Kukreja;Y. J. Huang;J. Wise;F. Svec;R. Richards;K. E. Friday;A. Vargas;R. Gómez;S. Chalew;M. Lan;Y. Tomer;N. Maclaren
关于非裔美国人对格雷夫斯病的遗传易感性的信息是有限的。我们使用基于PCR的序列特异性引发方法研究了49例非裔美国成人Graves病患者和47例种族匹配对照的DRB 1、DQB 1、DRB 3亚型、DQA 1 *0501、DQA 1 *0201和CTLA-4多态性。DRB 1、DQB 1等位基因频率及CTLA-4基因多态性在患者组和对照组之间无显著差异。然而，我们发现DRB 3在患者中的频率显著增加（75.5% vs.57.4%，P = 0.006，X2 = 3.52），尤其是DRB 3 *0202亚型（53.1% vs.23.4，P = 0.003，X2 = 8.91）。在这一方面，这一发现与我们以前在成年型Graves病白人患者中的观察结果一致。此外，尽管DQA 1 *0501的频率在我们的患者中增加（P = 0.018，X2 = 5.63），但DRB 3/DQA 1 *0501或DRB 3 *0202/DQA 1 *0501的单倍型被发现更强相关（分别为P = 0.008，X2 = 7.0; P = 0.0008，X2 = 11.34）。这些数据表明，DRB 3 *0202，特别是当在单倍型中与DQA 1 *0501一起发现时，是成年非裔美国人中格雷夫斯病的易感基因。考虑到这些数据与高加索患者，我们的研究结果表明，主要的格雷夫斯易感基因座可能是DRB 3，而不是DRB 1。
Information on genetic susceptibility to Graves' disease in African Americans is limited. We studied DRB1, DQB1, DRB3 subtypes, DQA1*0501, DQA1*0201, and CTLA-4 polymorphisms in 49 African American patients with adult onset Graves' disease and 47 racially-matched controls using PCR-based sequence-specific priming methods. There were no significant differences in DRB1 or DQB1 allelic frequencies or CTLA-4 polymorphisms between patients and controls. However, we found that the frequency of DRB3 was significantly increased in the patients (75.5% vs. 57.4%, P = 0.006, X2 = 3.52), especially for the DRB3*0202 subtype (53.1% vs. 23.4, P = 0.003, X2 = 8.91). In this one respect, the finding was in concordance with our previous observations in Caucasian patients with adult-onset Graves' disease. In addition, whereas the frequency of DQA1*0501 was increased (P = 0.018, X2 = 5.63) in our patients, the haplotype of DRB3/DQA1*0501, or DRB3*0202/DQA1*0501 was found to be more strongly associated (P = 0.008, X2 = 7.0; P = 0.0008, X2 = 11.34, respectively). These data suggest that DRB3*0202, particularly when found with DQA1*0501 in a haplotype is a susceptible gene(s) for Graves' disease in adult African Americans. Considering these data with those in Caucasian patients, our results would suggest that the primary Graves susceptible locus is likely DRB3 and not DRB1.
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HLA-DQA1*0501 与男性高加索人群中格雷夫斯病之间存在密切关联。
DOI：
10.1210/jcem.79.1.8027232
发表时间：
1994
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Yanagawa,T;Mangklabruks,A;DeGroot,LJ
通讯作者：
DeGroot,LJ
人类白细胞抗原等位基因 DQA1*0501 与格雷夫斯病之间缺乏独立关联。
DOI：
10.1210/jcem.81.2.8636314
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Cuddihy,RM;Bahn,RS
通讯作者：
Bahn,RS
患有格雷夫斯病的非裔美国女性患者的 HLA II 类关联。
DOI：
10.1089/thy.1996.6.37
发表时间：
1996
期刊：
Thyroid : official journal of the American Thyroid Association.
影响因子：
--
作者：
Yanagawa,T;DeGroot,LJ
通讯作者：
DeGroot,LJ
非裔美国人 HLA II 类等位基因和单倍型多样性。
影响因子：
--
作者：
Just,JJ;King,MC;Thomson,G;Klitz,W
通讯作者：
Klitz,W
影响因子：
5.8
作者：
YANAGAWA, T;MANGKLABRUKS, A;DEGROOT, LJ
通讯作者：
DEGROOT, LJ