HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection.
HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection.
复制标题
早期感染过程中宿主微管细胞骨架的HIV-1衣壳剥离。
DOI：
10.1186/s12977-021-00563-3
复制
发表时间：
2021-07-06
期刊：
影响因子：
3.3
通讯作者：
Naghavi MH
中科院分区：
文献类型：
--
作者：
Naghavi MH
Microtubules (MTs) form a filamentous array that provide both structural support and a coordinated system for the movement and organization of macromolecular cargos within the cell. As such, they play a critical role in regulating a wide range of cellular processes, from cell shape and motility to cell polarization and division. The array is radial with filament minus-ends anchored at perinuclear MT-organizing centers and filament plus-ends continuously growing and shrinking to explore and adapt to the intracellular environment. In response to environmental cues, a small subset of these highly dynamic MTs can become stabilized, acquire post-translational modifications and act as specialized tracks for cargo trafficking. MT dynamics and stability are regulated by a subset of highly specialized MT plus-end tracking proteins, known as +TIPs. Central to this is the end-binding (EB) family of proteins which specifically recognize and track growing MT plus-ends to both regulate MT polymerization directly and to mediate the accumulation of a diverse array of other +TIPs at MT ends. Moreover, interaction of EB1 and +TIPs with actin-MT cross-linking factors coordinate changes in actin and MT dynamics at the cell periphery, as well as during the transition of cargos from one network to the other. The inherent structural polarity of MTs is sensed by specialized motor proteins. In general, dynein directs trafficking of cargos towards the minus-end while most kinesins direct movement toward the plus-end. As a pathogenic cargo, HIV-1 uses the actin cytoskeleton for short-range transport most frequently at the cell periphery during entry before transiting to MTs for long-range transport to reach the nucleus. While the fundamental importance of MT networks to HIV-1 replication has long been known, recent work has begun to reveal the underlying mechanistic details by which HIV-1 engages MTs after entry into the cell. This includes mimicry of EB1 by capsid (CA) and adaptor-mediated engagement of dynein and kinesin motors to elegantly coordinate early steps in infection that include MT stabilization, uncoating (conical CA disassembly) and virus transport toward the nucleus. This review discusses recent advances in our understanding of how MT regulators and their associated motors are exploited by incoming HIV-1 capsid during early stages of infection.
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DOI：
10.1038/nrmicro3503
发表时间：
2015-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Campbell EM;Hope TJ
通讯作者：
Hope TJ
DOI：
10.1016/b978-0-12-386039-2.00004-3
发表时间：
2011
影响因子：
--
作者：
Desiniotis A;Kyprianou N
通讯作者：
Kyprianou N
影响因子：
64.5
作者：
Akhmanova, A;Hoogenraad, CC;Galjart, N
通讯作者：
Galjart, N
DOI：
10.1073/pnas.1700247114
发表时间：
2017-08-15
影响因子：
11.1
作者：
Delaney, Michael Keegan;Malikov, Viacheslav;Naghavi, Mojgan H.
通讯作者：
Naghavi, Mojgan H.
影响因子：
15.3
作者：
del Real, G;Jiménez-Baranda, S;Mañes, S
通讯作者：
Mañes, S