Chromatin compaction in terminally differentiated avian blood cells: the role of linker histone H5 and non-histone protein MENT.
Chromatin compaction in terminally differentiated avian blood cells: the role of linker histone H5 and non-histone protein MENT.
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DOI:
10.1007/s10577-011-9218-3
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发表时间:
2011-07
影响因子:
2.6
通讯作者:
Palyga, Jan
中科院分区:
文献类型:
--
作者:
Kowalski, Andrzej;Palyga, Jan
Chromatin has a tendency to shift from a relatively decondensed (active) to condensed (inactive) state during cell differentiation due to interactions of specific architectural and/or regulatory proteins with DNA. A promotion of chromatin folding in terminally differentiated avian blood cells requires the presence of either histone H5 in erythrocytes or non-histone protein, myeloid and erythroid nuclear termination stage-specific protein (MENT), in white blood cells (lymphocytes and granulocytes). These highly abundant proteins assist in folding of nucleosome arrays and self-association of chromatin fibers into compacted chromatin structures. Here, we briefly review structural aspects and molecular mode of action by which these unrelated proteins can spread condensed chromatin to form inactivated regions in the genome.
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DOI:
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期刊:
Biochemistry and cell biology = Biochimie et biologie cellulaire
影响因子:
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