Chromatin compaction in terminally differentiated avian blood cells: the role of linker histone H5 and non-histone protein MENT.

Chromatin compaction in terminally differentiated avian blood cells: the role of linker histone H5 and non-histone protein MENT.
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DOI:
10.1007/s10577-011-9218-3
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发表时间:
2011-07
影响因子:
2.6
通讯作者:
Palyga, Jan
Palyga, Jan
中科院分区:
生物学2区
文献类型:
--
作者:
Kowalski, Andrzej;Palyga, Jan

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由于特定结构和/或调节蛋白与 DNA 的相互作用,在细胞分化过程中,染色质倾向于从相对解压缩(活性)状态转变为压缩(非活性)状态。在终末分化的禽类血细胞中促进染色质折叠需要红细胞中存在组蛋白 H5 或白细胞(淋巴细胞和粒细胞)中存在非组蛋白、骨髓和红细胞核终止阶段特异性蛋白 (MENT)。这些高度丰富的蛋白质有助于核小体阵列的折叠和染色质纤维的自缔合形成致密的染色质结构。在这里,我们简要回顾了结构方面和分子作用模式,这些不相关的蛋白质可以通过这些模式传播浓缩的染色质以在基因组中形成失活区域。
Chromatin has a tendency to shift from a relatively decondensed (active) to condensed (inactive) state during cell differentiation due to interactions of specific architectural and/or regulatory proteins with DNA. A promotion of chromatin folding in terminally differentiated avian blood cells requires the presence of either histone H5 in erythrocytes or non-histone protein, myeloid and erythroid nuclear termination stage-specific protein (MENT), in white blood cells (lymphocytes and granulocytes). These highly abundant proteins assist in folding of nucleosome arrays and self-association of chromatin fibers into compacted chromatin structures. Here, we briefly review structural aspects and molecular mode of action by which these unrelated proteins can spread condensed chromatin to form inactivated regions in the genome.
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