Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1.
Deregulation of microRNA-193b affects the proliferation of liver cancer via myeloid cell leukemia-1.
复制标题
MicroRNA-193B的放松管制会通过髓样细胞白血病-1影响肝癌的增殖。
DOI：
10.3892/ol.2017.7690
复制
发表时间：
2018-03
期刊：
影响因子：
2.9
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Yin W;Nie Y;Chen L;Wang Q;Liu S;He X;Wang W
microRNA（miR）-193b的失调已被揭示与肝细胞的增殖相关。然而，miR-193 b与其诱导肝癌的靶点之间的相互作用在很大程度上仍然未知。本研究的目的是探讨miR-193 b影响肝癌细胞增殖的假说。在本研究中，与肝癌患者和miR-193 b高倍数变化的患者相比，肝癌患者和miR-193 b低倍数变化的患者的总生存率更高。肝癌患者骨髓细胞白血病-1（Mcl-1）的表达水平低于对照组。本研究结果表明，下调miR-193 b可抑制肝癌细胞的增殖并诱导其凋亡，抑制肝癌细胞中Mcl-1蛋白的表达水平。上调miR-193 b可促进肝癌细胞增殖，降低凋亡，并促进Mcl-1蛋白的表达。本研究的结果表明，miR-193 b作为一种新的肿瘤抑制因子的表达通过介导Mcl-1的表达在肝癌细胞的增殖中起重要作用。
Deregulation of microRNA (miR)-193b has been revealed to be associated with the proliferation of liver cells. However, the interaction between miR-193b and their targets inducing liver cancer remains largely unknown. The aim of the present study was to investigate the hypothesis that miR-193b affects the proliferation of liver cancer cells. In the present study, the overall survival of patients with liver cancer and low fold change of miR-193b was higher compared with that of patients with liver cancer patients and high fold change of miR-193b. The expression level of myeloid cell leukemia-1 (Mcl-1) in patients with liver cancer was lower compared with in the control group. The results of the present study demonstrated that downregulation of miR-193b suppressed the proliferation and induced apoptosis of liver cancer cells, and inhibited the Mcl-1 protein expression level in liver cancer cells. Upregulation of miR-193b increased cell proliferation and decreased apoptosis of liver cancer cells and promoted the expression level of Mcl-1 protein. The results of the present study demonstrated that the expression of miR-193b as a novel tumor suppressor serves an important role in the proliferation of liver cancer cells by mediating Mcl-1 expression.
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DOI：
10.1016/j.jtcvs.2014.07.104
发表时间：
2014-12
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Sabe AA;Elmadhun NY;Sadek AA;Chu LM;Bianchi C;Sellke FW
通讯作者：
Sellke FW
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作者：
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影响因子：
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