Intrinsically disordered proteins play diverse roles in cell signaling.
Intrinsically disordered proteins play diverse roles in cell signaling.
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DOI：
10.1186/s12964-022-00821-7
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发表时间：
2022-02-17
期刊：
影响因子：
--
通讯作者：
Uversky VN
中科院分区：
文献类型：
--
作者：
Bondos SE;Dunker AK;Uversky VN
信号通路允许细胞检测和响应各种化学（例如Ca2+或趋化因子蛋白）和物理刺激（例如，纯粹应力、光）。这些通路共同形成了一个广泛的通信网络，调节基本的细胞活动并协调多个细胞或组织的功能。细胞信号传导过程对构成这些通路的蛋白质提出了许多要求，包括形成活性和非活性状态以及参与多种蛋白质相互作用的能力。此外，成功的信号传递通常需要放大信号，调节或调整对信号的响应，组合来自多个途径的信息，同时确保过程的保真度。这种敏感性、适应性和可调性是可能的，部分原因是在参与细胞信号传导的许多蛋白质中包含了固有的无序区域。这个集合的目标是突出内在障碍在细胞信号传导中的许多作用。在概述了可用于研究内在无序蛋白的资源之后，本文综述了内在无序蛋白在广泛多样的生物体中的信号传导的关键作用（动物、植物、细菌、真菌），在每一类细胞信号通路中，在细胞信号传导过程中的每个阶段（自分泌、外分泌、内分泌、旁分泌和内分泌）和每个阶段（配体、受体、转导子、效应子、终止子），细胞信号传导过程中的细胞信号传导都是相互作用的。因此，如果不了解内在无序的蛋白质区域如何促进其功能，就不能完全描述细胞信号传导途径。在不同的细胞信号通路的不同阶段普遍存在的内在障碍表明，更多的机制，障碍调节细胞内和细胞间的信号仍有待发现。
Signaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca2+ or chemokine proteins) and physical stimuli (e.g., sheer stress, light). Together, these pathways form an extensive communication network that regulates basic cell activities and coordinates the function of multiple cells or tissues. The process of cell signaling imposes many demands on the proteins that comprise these pathways, including the abilities to form active and inactive states, and to engage in multiple protein interactions. Furthermore, successful signaling often requires amplifying the signal, regulating or tuning the response to the signal, combining information sourced from multiple pathways, all while ensuring fidelity of the process. This sensitivity, adaptability, and tunability are possible, in part, due to the inclusion of intrinsically disordered regions in many proteins involved in cell signaling. The goal of this collection is to highlight the many roles of intrinsic disorder in cell signaling. Following an overview of resources that can be used to study intrinsically disordered proteins, this review highlights the critical role of intrinsically disordered proteins for signaling in widely diverse organisms (animals, plants, bacteria, fungi), in every category of cell signaling pathway (autocrine, juxtacrine, intracrine, paracrine, and endocrine) and at each stage (ligand, receptor, transducer, effector, terminator) in the cell signaling process. Thus, a cell signaling pathway cannot be fully described without understanding how intrinsically disordered protein regions contribute to its function. The ubiquitous presence of intrinsic disorder in different stages of diverse cell signaling pathways suggest that more mechanisms by which disorder modulates intra- and inter-cell signals remain to be discovered.
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影响因子：
13.8
作者：
Baldwin, RL;Rose, GD
通讯作者：
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影响因子：
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作者：
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作者：
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DOI：
10.1073/pnas.1911489116
发表时间：
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影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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