Effects of cue-triggered expectation on cortical processing of taste.

Effects of cue-triggered expectation on cortical processing of taste.
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DOI:
10.1016/j.neuron.2012.02.031
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发表时间:
2012-04-26
期刊:
影响因子:
16.2
通讯作者:
Fontanini A
Fontanini A
中科院分区:
医学1区
文献类型:
--
作者:
Samuelsen CL;Gardner MP;Fontanini A

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动物不是它们所生活的感官世界的被动观众。在自然条件下,他们经常根据预测线索引发的预期来感知物体。期望通过改变皮层网络的背景状态和调节感觉处理来深刻地调节神经活动。这两种影响之间的联系尚不清楚。在这里,我们研究了如何线索触发的预期刺激的可用性影响处理的感觉刺激的味觉皮层(GC)。我们发现,预期的tastants编码更迅速比意想不到的刺激。更快的感觉编码的启动与GC的预期启动相关的联想听觉线索。GC和基底外侧杏仁核的同步记录和药理学操作揭示了自上而下的输入在介导预期线索效应中的作用。总之,这些数据提供了一个新的模型,提示触发的期望如何改变感觉皮层的状态,以实现快速处理自然刺激。
Animals are not passive spectators of the sensory world in which they live. In natural conditions they often sense objects on the bases of expectations initiated by predictive cues. Expectation profoundly modulates neural activity by altering the background state of cortical networks and modulating sensory processing. The link between these two effects is not known. Here, we studied how cue-triggered expectation of stimulus availability influences processing of sensory stimuli in the gustatory cortex (GC). We found that expected tastants were coded more rapidly than unexpected stimuli. The faster onset of sensory coding related to anticipatory priming of GC by associative auditory cues. Simultaneous recordings and pharmacological manipulations of GC and basolateral amygdala revealed the role of top-down inputs in mediating the effects of anticipatory cues. Altogether these data provide a new model for how cue-triggered expectation changes the state of sensory cortices to achieve rapid processing of natural stimuli.
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