Chlamydomonas Basal Bodies as Flagella Organizing Centers.
Chlamydomonas Basal Bodies as Flagella Organizing Centers.
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DOI:
10.3390/cells7070079
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发表时间:
2018-07-17
期刊:
影响因子:
6
通讯作者:
Lechtreck KF
中科院分区:
文献类型:
--
作者:
Wingfield JL;Lechtreck KF
During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme. The discovery that many human diseases and developmental disorders result from defects in flagella has fueled a strong interest in the analysis of flagellar assembly. Here, we will review the structure, function, and development of basal bodies in the unicellular green alga Chlamydomonas reinhardtii, a widely used model for the analysis of basal bodies and flagella. Intraflagellar transport (IFT), a flagella-specific protein shuttle critical for ciliogenesis, was first described in C. reinhardtii. A focus of this review will be on the role of the basal bodies in organizing the IFT machinery.
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影响因子:
10.1
作者:
Brown JM;Witman GB
通讯作者:
Witman GB
影响因子:
7.8
作者:
Galati, Domenico F.;Bonney, Stephanie;Pearson, Chad G.
通讯作者:
Pearson, Chad G.
影响因子:
2.9
作者:
GAFFAL, KP;ELGAMMAL, S
通讯作者:
ELGAMMAL, S
影响因子:
1.5
作者:
FAWCETT, DW;PORTER, KR
通讯作者:
PORTER, KR
影响因子:
2.9
作者:
BEECH, PL;HEIMANN, K;MELKONIAN, M
通讯作者:
MELKONIAN, M