Chlamydomonas Basal Bodies as Flagella Organizing Centers.

Chlamydomonas Basal Bodies as Flagella Organizing Centers.
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DOI:
10.3390/cells7070079
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发表时间:
2018-07-17
期刊:
影响因子:
6
通讯作者:
Lechtreck KF
Lechtreck KF
中科院分区:
生物学2区
文献类型:
--
作者:
Wingfield JL;Lechtreck KF

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During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme. The discovery that many human diseases and developmental disorders result from defects in flagella has fueled a strong interest in the analysis of flagellar assembly. Here, we will review the structure, function, and development of basal bodies in the unicellular green alga Chlamydomonas reinhardtii, a widely used model for the analysis of basal bodies and flagella. Intraflagellar transport (IFT), a flagella-specific protein shuttle critical for ciliogenesis, was first described in C. reinhardtii. A focus of this review will be on the role of the basal bodies in organizing the IFT machinery.
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